| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PP17; TIP47; M6PRBP1 |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PLIN3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PLIN3抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*"Perilipin 3 modulates lipid droplet formation in human adipocytes"*
**作者**：Doe J. et al.
**摘要**：研究通过PLIN3抗体进行免疫荧光染色，揭示PLIN3在脂肪细胞脂滴组装中的关键作用，表明其调控脂质存储与水解的平衡。
2. **文献名称**：*"PLIN3 regulates autophagy-dependent lipid catabolism in hepatocytes"*
**作者**：Smith R. et al.
**摘要**：利用PLIN3抗体的Western blot和敲除实验，证明PLIN3通过结合自噬蛋白LC3.促进肝细胞脂质分解，与非酒精性脂肪肝病理相关。
3. **文献名称**：*"PLIN3 expression correlates with cancer progression in colorectal carcinoma"*
**作者**：Chen L. et al.
**摘要**：通过免疫组化分析(使用PLIN3抗体)发现，PLIN3在结直肠癌组织中高表达，且与肿瘤转移和患者预后不良显著相关，提示其作为潜在生物标志物。
(注：以上文献为示例，实际引用需根据具体研究核实。)
PLIN3 (Perilipin 3), also known as TIP47 (Tail-Interacting Protein of 47 kDa), is a member of the perilipin family of lipid droplet (LD)-associated proteins that regulate intracellular lipid storage and metabolism. It is ubiquitously expressed and plays a critical role in LD formation, stabilization, and trafficking by coating the surface of nascent LDs and interacting with proteins involved in lipid mobilization. PLIN3 is distinct from other perilipins (e.g., PLIN1 or PLIN2) due to its broader tissue distribution and involvement in both adipocyte and non-adipocyte lipid homeostasis.
PLIN3 antibodies are essential tools for studying its expression, localization, and function in metabolic processes. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate PLIN3's role in diseases linked to lipid dysregulation, such as obesity, diabetes, hepatic steatosis, and atherosclerosis. Research has also implicated PLIN3 in cancer progression, where altered lipid metabolism supports tumor growth.
Recent studies highlight PLIN3's interaction with autophagy machinery and its response to cellular stress, making it a biomarker for metabolic adaptation. Antibodies targeting specific PLIN3 epitopes help dissect these mechanisms, offering insights into therapeutic strategies for metabolic disorders and cancer. Validation of PLIN3 antibodies ensures specificity, given the structural similarities among perilipin family members.
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