| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TIM17; TIM17A |
| WB Predicted band size | 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TIMM17A抗体的3篇示例参考文献(注：文献信息为示例，非真实存在)：
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1. **文献名称**: "TIMM17A regulates mitochondrial protein import and neuronal survival in Alzheimer's disease models"
**作者**: Chen L, et al. (2021)
**摘要**: 本研究利用TIMM17A抗体验证了阿尔茨海默病模型中TIMM17A蛋白表达的下调，并发现其功能障碍导致线粒体蛋白输入受损，加剧神经元凋亡。
2. **文献名称**: "A novel monoclonal antibody against TIMM17A reveals its dynamic localization in mitochondrial membrane complexes"
**作者**: Müller S, et al. (2018)
**摘要**: 开发了一种高特异性TIMM17A单克隆抗体，通过免疫共沉淀和免疫荧光技术，揭示了TIMM17A在线粒体内膜复合体中的动态定位及其与TIM23复合体的相互作用。
3. **文献名称**: "TIMM17A as a biomarker in colorectal cancer: Antibody-based detection and clinical correlations"
**作者**: Wang Y, et al. (2020)
**摘要**: 通过TIMM17A抗体检测结直肠癌组织样本，发现TIMM17A表达水平与肿瘤进展和化疗耐药性显著相关，提示其作为潜在治疗靶点。
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如需真实文献，建议在PubMed或Google Scholar检索关键词“TIMM17A antibody”、“TIMM17A function”或结合具体研究领域(如神经退行性疾病、癌症等)。
The TIMM17A antibody is a research tool designed to detect and study the Translocase of Inner Mitochondrial Membrane 17A (TIMM17A), a key component of the mitochondrial protein import machinery. TIMM17A is a subunit of the TIM23 complex, which mediates the translocation of presequence-containing proteins from the cytosol into the mitochondrial matrix. This ~17 kDa protein is embedded in the inner mitochondrial membrane and plays a critical role in maintaining the structural integrity of the TIM23 channel, facilitating precursor protein recognition and membrane potential-dependent transport. Dysregulation of TIMM17A has been implicated in mitochondrial dysfunction linked to neurodegenerative disorders, cancer, and metabolic diseases.
TIMM17A antibodies are commonly generated in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable applications such as Western blotting, immunofluorescence, and immunoprecipitation to investigate TIMM17A expression levels, subcellular localization, and protein-protein interactions. Validation typically includes testing on knockout cell lines or tissues to confirm specificity. Researchers utilize these antibodies to explore mitochondrial import mechanisms, cellular stress responses, and disease-associated mitochondrial defects. Commercial TIMM17A antibodies often show reactivity across human, mouse, and rat samples, making them versatile for cross-species studies. Proper experimental controls, such as mitochondrial markers and loading controls, are essential when using this antibody to ensure accurate interpretation of mitochondrial protein dynamics.
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