Rabbit Polyclonal TRIM14 Antibody

The TRIM14 antibody is a research tool designed to detect and study TRIM14. a protein belonging to the tripartite motif (TRIM) family. TRIM proteins are characterized by conserved RING, B-box, and coiled-coil domains, and they play diverse roles in cellular processes, including innate immunity, antiviral defense, and cancer. TRIM14 has garnered attention for its dual roles in immune regulation and disease pathogenesis. It functions as a positive regulator of innate immune signaling, particularly enhancing type I interferon (IFN) responses by stabilizing key adaptors like MITA/STING during viral infections. Conversely, TRIM14 has been implicated in promoting cancer progression, metastasis, and chemoresistance in various malignancies, often through mechanisms involving NF-κB activation or autophagy modulation. The TRIM14 antibody enables researchers to investigate its expression, subcellular localization, and interactions in cells and tissues using techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Validated antibodies are critical for elucidating TRIM14's context-dependent roles—whether in antiviral immunity, inflammatory diseases, or tumor biology—and for exploring its potential as a therapeutic target. However, variability in antibody specificity and validation across commercial sources requires careful selection to ensure experimental accuracy. Ongoing research continues to unravel TRIM14's complex functions, emphasizing the antibody's importance in bridging molecular insights to clinical applications.