| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TMTSP; UNQ3010 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human THSD1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于THSD1抗体的3篇示例参考文献(注：内容为示例性概括，非真实文献)：
1. **文献名称**：*THSD1 modulates endothelial cell permeability and angiogenesis via integrin signaling*
**作者**：Smith A, et al.
**摘要**：本研究利用THSD1特异性抗体，通过免疫荧光和Western blot分析发现THSD1通过调控整合素β1信号通路影响内皮细胞通透性和血管生成，提示其在血管疾病中的潜在作用。
2. **文献名称**：*THSD1 deficiency promotes intracranial hemorrhage through disruption of the blood-brain barrier*
**作者**：Chen L, et al.
**摘要**：通过THSD1抗体检测小鼠脑组织发现，THSD1缺失导致血脑屏障结构蛋白(如ZO-1)表达下降，证实THSD1在维持脑血管稳定性中的关键功能，可能与脑出血病理机制相关。
3. **文献名称**：*Development and validation of a monoclonal antibody against THSD1 for cancer biomarker studies*
**作者**：Wang Y, et al.
**摘要**：文章报道了一种新型THSD1单克隆抗体的开发，验证其在免疫组化中的特异性，并发现THSD1在胶质瘤血管中的高表达，提示其作为肿瘤血管标志物的潜力。
(注：以上文献为模拟内容，实际研究中请通过学术数据库检索具体文献。)
**Background of THSD1 Antibody**
Thrombospondin type-1 domain-containing protein 1 (THSD1) is a member of the thrombospondin family, known for its role in cell adhesion, angiogenesis, and vascular stability. It interacts with integrins and extracellular matrix components, influencing signaling pathways critical for endothelial cell function and blood vessel integrity. THSD1 is implicated in maintaining cerebrovascular homeostasis, with studies linking its dysfunction to conditions like preeclampsia, intracranial hemorrhage, and stroke.
THSD1 antibodies are essential tools for detecting and quantifying THSD1 expression in research. They enable the investigation of its localization, interaction partners, and mechanistic roles in vascular biology and disease. Polyclonal and monoclonal THSD1 antibodies are generated using immunogenic peptide sequences or recombinant protein fragments, often validated in techniques such as Western blotting, immunohistochemistry, and immunofluorescence.
Recent studies highlight THSD1's involvement in regulating endothelial permeability and cytoskeletal dynamics, suggesting its potential as a therapeutic target. Antibodies against THSD1 have been pivotal in uncovering its association with pathological angiogenesis and blood-brain barrier disruption. Commercial availability of THSD1 antibodies has accelerated research into its diagnostic or prognostic value in vascular disorders, though further validation is needed for clinical applications. Overall, THSD1 antibodies remain crucial for elucidating its biological significance and translational potential.
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