| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | EBAF; LEFTA; TGFB4; LEFTYA |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LEFTY2抗体的3篇参考文献的示例(注：文献信息为示例，实际引用请核实原文)：
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1. **文献名称**: "Left-right asymmetry in embryonic development: role of Lefty2 in the mouse"
**作者**: Meno, C. et al.
**摘要**: 该研究利用LEFTY2抗体在小鼠胚胎中检测蛋白表达，发现LEFTY2通过拮抗Nodal信号通路调控胚胎左右轴形成，揭示了其在早期发育中的关键作用。
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2. **文献名称**: "Lefty2 as a biomarker in ovarian cancer progression"
**作者**: Tanaka, M. et al.
**摘要**: 通过免疫组化(使用LEFTY2抗体)分析卵巢癌组织，发现LEFTY2高表达与肿瘤转移和不良预后相关，提示其可作为潜在治疗靶点。
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3. **文献名称**: "Regulation of TGF-β signaling by Lefty2 in human embryonic stem cells"
**作者**: Saijoh, Y. et al.
**摘要**: 研究使用LEFTY2抗体进行蛋白质印迹和免疫荧光实验，证实LEFTY2通过抑制Smad2/3磷酸化调控TGF-β通路，影响人胚胎干细胞的自我更新与分化。
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4. **文献名称**: "Lefty2 antibody-based detection in breast cancer metastasis"
**作者**: Chung, J. et al.
**摘要**: 利用LEFTY2抗体的ELISA和免疫组化方法，发现LEFTY2在乳腺癌转移患者的血清中显著升高，提示其作为液体活检标志物的潜力。
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(注：以上文献为示例，实际研究请参考PubMed或SciFinder等数据库的权威文献。)
The LEFTY2 antibody is a crucial tool in studying the role of LEFTY2 (Left-Right Determination Factor 2), a secreted protein belonging to the TGF-β (transforming growth factor-beta) superfamily. LEFTY2. also known as endometrial bleeding-associated factor (Ebaf), is primarily involved in embryonic development, particularly in establishing left-right asymmetry during organogenesis. It acts as an antagonist of Nodal and BMP (bone morphogenetic protein) signaling pathways, regulating cell differentiation, tissue patterning, and stem cell maintenance. Dysregulation of LEFTY2 has been linked to developmental disorders, cancer progression, and reproductive health issues, including endometrial remodeling and recurrent pregnancy loss.
LEFTY2 antibodies are widely used in research to detect and quantify LEFTY2 protein expression in various biological samples through techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate LEFTY2's spatial-temporal expression patterns, its interactions with signaling molecules, and its role in pathological conditions. For instance, studies using LEFTY2 antibodies have revealed its tumor-suppressive effects in certain cancers by inhibiting epithelial-mesenchymal transition (EMT), while other research highlights its involvement in immune modulation and tissue fibrosis. The development of specific, high-affinity LEFTY2 antibodies continues to advance our understanding of developmental biology, oncology, and regenerative medicine.
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