| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | Rhes; TEM2; MGC:4834 |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RASD2抗体的部分文献示例(内容基于公开研究归纳，非真实引用)：
1. **《RASD2在神经内分泌系统中的表达调控》**
*作者：Smith A et al.*
摘要：本研究利用新型兔源多克隆RASD2抗体，通过免疫印迹和免疫组化技术，揭示了RASD2蛋白在下丘脑和垂体中的特异性表达模式，并发现其表达受激素刺激的动态调节。
2. **《RASD2抗体在帕金森病模型中的验证与应用》**
*作者：Chen L & Wang Y*
摘要：文章报道了一种高特异性小鼠单克隆RASD2抗体的开发，验证其在脑组织切片中的结合效率，并发现RASD2在黑质多巴胺能神经元中的表达缺失与帕金森病模型相关。
3. **《RASD2与G蛋白偶联受体信号通路的相互作用研究》**
*作者：Garcia R et al.*
摘要：通过商业化RASD2抗体(货号AB123.ABC公司)进行免疫共沉淀实验，首次证明RASD2与特定GPCR受体(如β2-肾上腺素受体)存在直接相互作用，影响细胞内cAMP信号传导。
4. **《癌症中RASD2抗体检测的临床意义》**
*作者：Kim H et al.*
摘要：使用免疫组织化学方法评估500例结直肠癌样本，发现RASD2蛋白高表达(经两种独立抗体交叉验证)与患者生存率正相关，提示其作为潜在预后标志物的价值。
**注**：以上为模拟内容，实际文献需通过PubMed/Google Scholar检索关键词“RASD2 antibody”或“RASD2 immunohistochemistry”获取。部分关键研究可能聚焦于RASD2功能而非抗体本身，但会包含抗体使用方法的描述。
The RASD2 antibody is designed to detect RASD2. a GTP-binding protein belonging to the RAS superfamily. Also known as Dexras1 or AGS1. RASD2 plays roles in G protein-coupled receptor (GPCR) signaling, cellular differentiation, and circadian rhythm regulation. It is highly expressed in the brain, particularly in regions like the suprachiasmatic nucleus, linking it to neurological functions and disorders. RASD2 interacts with various signaling molecules, including nitric oxide synthase and the melatonin receptor, and is implicated in stress responses, neuronal survival, and post-translational modifications such as SUMOylation.
Antibodies targeting RASD2 are essential tools in studying its expression, localization, and molecular interactions. They enable applications like Western blotting, immunohistochemistry, and immunofluorescence, aiding research in neurobiology, cancer (due to its dysregulation in tumors), and metabolic diseases. These antibodies are often validated for specificity using knockout controls or siRNA-based knockdowns. Commercial RASD2 antibodies are typically raised in rabbits or mice, with clones available for different experimental needs. Researchers rely on them to explore RASD2’s potential as a therapeutic target or biomarker in conditions like neurodegenerative diseases, circadian disorders, and hormone-related cancers. Optimal performance depends on proper validation and protocol optimization, as cross-reactivity with other RAS proteins may occur.
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