| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及TFDP2抗体的参考文献(内容基于公开文献概括，具体文献标题和作者为模拟示例)：
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1. **文献名称**: *"TFDP2 regulates hepatocellular carcinoma progression through E2F1 target genes"*
**作者**: Li X, et al.
**摘要**: 本研究利用TFDP2抗体通过免疫组化分析肝癌组织中TFDP2蛋白表达水平，发现其高表达与患者预后不良相关。实验证明TFDP2通过调控E2F1靶基因促进肿瘤细胞增殖和迁移。
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2. **文献名称**: *"Characterization of a novel monoclonal antibody against human TFDP2 for functional studies"*
**作者**: Sato Y, et al.
**摘要**: 文章报道了一种特异性识别TFDP2的单克隆抗体的开发与验证，通过Western blot和免疫荧光证实其在不同细胞系中的特异性，并用于研究TFDP2在细胞周期调控中的作用。
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3. **文献名称**: *"TFDP2 interacts with MYC to drive oncogenic transcription in triple-negative breast cancer"*
**作者**: Gupta R, et al.
**摘要**: 研究利用TFDP2抗体进行染色质免疫共沉淀(ChIP)，揭示TFDP2与MYC蛋白协同结合靶基因启动子区，促进三阴性乳腺癌的致癌转录程序，为治疗靶点提供依据。
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注：以上文献标题及作者为示例性内容，实际文献需通过PubMed或学术数据库检索确认。
The TFDP2 antibody is a tool used to detect Transcription Factor Dp-2 (TFDP2), a member of the DP family of transcription regulators. TFDP2 forms heterodimers with E2F proteins, enabling sequence-specific DNA binding and transcriptional regulation of genes involved in cell cycle progression, apoptosis, and differentiation. Unlike its homolog TFDP1. TFDP2 exhibits distinct DNA-binding properties and tissue-specific expression patterns, with higher prevalence in certain tissues like the placenta and testis. It plays roles in embryonic development and cellular homeostasis, though its functional overlap or divergence with TFDP1 remains under investigation.
Research using TFDP2 antibodies has highlighted its dual roles in cancer biology. While some studies suggest TFDP2 acts as an oncogene by promoting cell proliferation and survival in cancers like hepatocellular carcinoma, others propose tumor-suppressive functions in contexts such as prostate cancer. This complexity may stem from tissue-specific interactions with E2Fs or other co-regulators. Additionally, TFDP2 has been implicated in neurodegenerative diseases and developmental disorders, reflecting its broad regulatory influence.
TFDP2 antibodies are critical for techniques like Western blotting, immunohistochemistry, and immunofluorescence, enabling the study of its expression, localization, and interactions. Their applications extend to exploring TFDP2's role in drug resistance, cellular senescence, and epigenetic modulation. Despite progress, challenges persist in distinguishing TFDP2-specific functions from those of TFDP1 due to structural similarities, necessitating rigorous antibody validation in experimental models.
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