| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于THAP2抗体的3篇虚构参考文献示例(仅供格式参考，实际文献需通过学术数据库查询)：
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1. **标题**: *THAP2 Expression in Colorectal Cancer: A Novel Tumor Suppressor Role*
**作者**: Zhang L, et al.
**摘要**: 本研究通过免疫组化(使用特异性THAP2抗体)分析结直肠癌组织中THAP2蛋白的表达，发现其表达水平显著下调，并与患者预后不良相关。机制研究表明THAP2通过调控Wnt/β-catenin通路抑制肿瘤生长。
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2. **标题**: *Characterization of a Monoclonal THAP2 Antibody for Chromatin Immunoprecipitation*
**作者**: Gomez-Rivas E, et al.
**摘要**: 文章报道了一种新型THAP2单克隆抗体的开发与验证，该抗体成功应用于ChIP-seq实验，揭示了THAP2在基因组中结合的区域及其在DNA损伤修复中的潜在调控作用。
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3. **标题**: *THAP2 Interaction with Cell Cycle Regulators: Evidence from Co-Immunoprecipitation*
**作者**: Tanaka K, et al.
**摘要**: 通过免疫共沉淀(使用THAP2抗体)和质谱分析，发现THAP2与细胞周期蛋白Cyclin D1和CDK6存在直接相互作用，提示其在G1/S期转换中的调控功能。
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**备注**：若实际文献较少，建议扩展检索关键词(如“THAP domain protein 2”或结合疾病名称)，或查阅抗体供应商(如Abcam、CST)提供的技术文档引用文献。
The THAP2 antibody is a tool used to detect THAP domain-containing apoptosis-associated protein 2 (THAP2), a member of the THAP family of DNA-binding proteins. THAP proteins are characterized by a conserved THAP domain, a zinc-coordinating motif that binds specific DNA sequences, enabling roles in transcriptional regulation, cell proliferation, and apoptosis. THAP2. though less studied than other family members (e.g., THAP1 or THAP9), is implicated in cellular processes such as cell cycle control, differentiation, and chromatin remodeling. Dysregulation of THAP2 has been tentatively linked to cancers and neurological disorders, though its precise mechanisms remain under investigation.
THAP2 antibodies are typically produced in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies are validated for applications such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF) to study THAP2 expression patterns in tissues or cultured cells. Researchers utilize these tools to explore THAP2's interaction partners, subcellular localization, and regulatory pathways. Specificity is confirmed via knockout controls or siRNA knockdown. While commercial THAP2 antibodies vary in clonality (monoclonal/polyclonal) and conjugations (e.g., HRP, fluorescent tags), thorough validation is essential due to potential cross-reactivity with homologous THAP proteins. Current studies focus on clarifying THAP2's role in disease models, particularly its tumor-suppressive or oncogenic functions, driving demand for reliable detection reagents.
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