Rabbit Polyclonal TRIM11 Antibody

The TRIM11 antibody is a tool used to detect and study TRIM11. a member of the tripartite motif (TRIM) protein family. TRIM proteins are characterized by conserved RING, B-box, and coiled-coil domains, and many function as E3 ubiquitin ligases involved in protein degradation, immune regulation, and antiviral responses. TRIM11. located on human chromosome 1. has been implicated in diverse cellular processes, including autophagy, cell cycle control, and tumorigenesis. It interacts with components of the ubiquitin-proteasome system, modulating protein stability and signaling pathways like NF-κB and p53. Research highlights its dual role in cancer, acting as an oncogene in certain contexts (e.g., promoting glioma proliferation) or a tumor suppressor in others. TRIM11 is also linked to neurodegenerative diseases, such as Alzheimer’s, by influencing amyloid-beta aggregation. Antibodies against TRIM11 are essential for detecting its expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These reagents aid in exploring its biological functions, pathological roles, and potential as a therapeutic target. Commercial TRIM11 antibodies vary in specificity, requiring validation using knockout controls to ensure reliability in experimental settings.