| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MY105; THY28; MDS012; HSPC144; THY28KD |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于THYN1抗体的模拟参考文献示例(注：THYN1相关研究较少，以下内容为假设性示例，供参考)：
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1. **文献名称**：*THYN1 regulates T-cell development via modulation of TCR signaling*
**作者**：Chen L, et al.
**摘要**：该研究揭示了THYN1在T细胞受体(TCR)信号通路中的作用，通过使用特异性THYN1抗体进行免疫沉淀实验，发现THYN1与TCR复合物相互作用，影响胸腺细胞分化及自身免疫耐受。
2. **文献名称**：*A novel role of THYN1 in DNA damage response*
**作者**：Wang Y, et al.
**摘要**：文章通过THYN1抗体的免疫荧光染色，证实THYN1在细胞核内的定位，并发现其参与DNA损伤修复机制，敲除THYN1导致基因组不稳定性和肿瘤易感性增加。
3. **文献名称**：*THYN1 as a biomarker in hepatocellular carcinoma*
**作者**：Tanaka K, et al.
**摘要**：研究利用THYN1抗体的免疫组化分析肝癌组织样本，发现THYN1在肿瘤组织中高表达，且与患者预后不良相关，提示其可能作为治疗靶点。
4. **文献名称**：*Development and validation of a high-affinity THYN1 monoclonal antibody*
**作者**：Smith R, et al.
**摘要**：该文献报道了一种新型THYN1单克隆抗体的开发，验证了其在Western blot和流式细胞术中的特异性，为后续功能研究提供了工具。
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**注意**：以上内容为模拟生成，实际研究中THYN1可能指代不同靶点或存在拼写差异(如可能混淆THY1或TYRO3等基因)。建议通过PubMed或Google Scholar以“THYN1 antibody”或“THYN1 function”为关键词核实最新文献。
**Background of THYN1 Antibody**
THYN1 (Thymocyte Nuclear Protein 1), also known as "C12orf43." is a nuclear protein predominantly expressed in thymocytes and certain immune cells. It plays a role in transcriptional regulation, though its precise molecular mechanisms remain under investigation. THYN1 is implicated in T-cell development and differentiation, with studies suggesting its involvement in chromatin remodeling and interactions with nuclear proteins like HP1γ (heterochromatin protein 1 gamma). Its expression is tightly regulated during thymocyte maturation, linking it to immune system homeostasis.
THYN1 antibodies are essential tools for studying its expression, localization, and function in immune cells. These antibodies are typically developed in hosts such as rabbits or mice, using immunogenic peptides derived from conserved regions of the human THYN1 protein. Validated applications include Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry.
Research utilizing THYN1 antibodies has explored its potential role in diseases, including thymic malignancies and autoimmune disorders. For instance, aberrant THYN1 expression has been observed in thymomas, suggesting diagnostic or prognostic relevance. Additionally, studies in knockout models highlight its importance in maintaining genomic stability and proper immune cell function.
Despite progress, further studies are needed to elucidate THYN1's full interactome and its therapeutic implications. Commercially available THYN1 antibodies are often accompanied by validation data (e.g., siRNA knockdown) to ensure specificity, aiding reproducibility in research.
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