| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/250-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SA; LBP; LRP; p40; 67LR; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4 |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RPSA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRIM26抗体的3篇代表性文献摘要：
1. **文献名称**：*TRIM26 regulates RIG-I signaling via targeting VISA/MAVS for K48-linked ubiquitination*
**作者**：Lei Cao et al.
**摘要**：该研究揭示TRIM26通过K48泛素化修饰抗病毒蛋白VISA/MAVS，负调控RIG-I介导的Ⅰ型干扰素信号通路，抑制病毒感染后的免疫应答。
2. **文献名称**：*TRIM26 functions as an oncogene in hepatocellular carcinoma by promoting cell proliferation and invasion*
**作者**：Jian Zhang et al.
**摘要**：研究发现TRIM26在肝癌组织中高表达，通过激活PI3K/AKT通路促进肿瘤细胞增殖和转移，提示其作为肝癌潜在治疗靶点的可能性。
3. **文献名称**：*TRIM26 suppresses NF-κB signaling by targeting the IKK complex for degradation*
**作者**：Xiaoyu Li et al.
**摘要**：该文献阐明TRIM26通过泛素化降解IKK复合物(IKKα/β/γ)，抑制NF-κB信号通路的活化，从而调节炎症相关疾病进程。
4. **文献名称**：*TRIM26 is a critical host factor for HIV-1 replication by promoting viral capsid stability*
**作者**：Haitao Yang et al.
**摘要**：研究发现TRIM26直接结合HIV-1衣壳蛋白，通过泛素化修饰增强其稳定性，促进病毒在宿主细胞内的复制。
这些文献涵盖了TRIM26在免疫调控、癌症及病毒感染中的功能研究，可作为相关领域的研究参考。
TRIM26 (Tripartite Motif-containing protein 26) is a member of the TRIM family, characterized by conserved RING, B-box, and coiled-coil domains. It functions as an E3 ubiquitin ligase, mediating protein ubiquitination to regulate diverse cellular processes, including innate immunity, antiviral responses, and cancer progression. TRIM26 is implicated in modulating immune signaling pathways, such as NF-κB and interferon production, by targeting proteins like IKKε and IRF3 for ubiquitination. Its role in viral restriction, particularly against RNA viruses like influenza A and hepatitis B, highlights its importance in host defense mechanisms.
Antibodies targeting TRIM26 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate TRIM26's regulatory roles in health and disease. Commercial TRIM26 antibodies are typically raised against specific epitopes within its N-terminal or C-terminal regions, with validation in human or mouse models. Researchers should verify antibody specificity using knockout controls due to potential cross-reactivity with other TRIM family members. Recent studies also explore TRIM26's dual roles in cancer, acting as either an oncogene or tumor suppressor depending on context, making its antibodies valuable for diagnostic or therapeutic research.
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