| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | WDM; ALS26; TIA-1 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TIA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TIA1抗体的3篇代表性文献(简要概括，非真实文献，仅供示例参考)：
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1. **文献名称**：*TIA1 Autoantibodies as a Biomarker in Idiopathic Inflammatory Myopathies*
**作者**：Mammen AL, et al.
**摘要**：研究发现TIA1抗体在部分坏死性肌炎患者血清中特异性存在，提示其可能作为区分肌炎亚型的生物标志物，并可能与疾病活动度和治疗反应相关。
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2. **文献名称**：*TIA1 Dysregulation in Cancer: Prognostic Implications*
**作者**：Zhang Y, et al.
**摘要**：通过免疫组化分析发现，TIA1蛋白在结直肠癌组织中表达水平降低，且与患者预后不良相关，提示TIA1可能通过调控肿瘤细胞凋亡影响癌症进展。
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3. **文献名称**：*Mechanistic Role of TIA1 in Stress Granule Formation and Neurodegeneration*
**作者**：Parker SJ, Wolozin B
**摘要**：研究揭示了TIA1蛋白在应激颗粒组装中的关键作用，并发现其异常聚集可能导致肌萎缩侧索硬化症(ALS)等神经退行性疾病的病理过程。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“TIA1 antibody”或“anti-TIA1”，并筛选临床或机制研究相关论文。
**Background of TIA1 Antibody**
TIA1 (T-cell intracellular antigen 1) is a cytotoxic granule-associated RNA-binding protein primarily expressed in immune cells, including cytotoxic T lymphocytes and natural killer (NK) cells. It plays dual roles in RNA metabolism and apoptosis. Structurally, TIA1 contains three RNA recognition motifs (RRMs) that mediate its interaction with target mRNAs, regulating splicing, translation, and stress-induced RNA granule formation. During cellular stress, TIA1 promotes the sequestration of non-essential mRNAs into stress granules, halting their translation to conserve resources.
In immune responses, TIA1 is critical for cytotoxicity, as it is stored in cytotoxic granules and released to induce apoptosis in target cells by cleaving DNA. Dysregulation of TIA1 has been linked to autoimmune diseases, neurodegenerative disorders, and cancers. For instance, altered TIA1 expression is observed in conditions like amyotrophic lateral sclerosis (ALS) and inclusion body myositis (IBM), where abnormal protein aggregation occurs.
TIA1 antibodies, used in research and diagnostics, help detect TIA1 protein expression in tissues or cell lines. They are valuable tools for studying stress granule dynamics, immune cell function, and disease mechanisms. In clinical pathology, TIA1 immunohistochemistry aids in identifying cytotoxic lymphocytes in inflammatory or neoplastic contexts. Recent studies also explore TIA1's role in modulating immune checkpoints, highlighting its therapeutic potential. Overall, TIA1 antibodies bridge molecular insights with clinical applications in immunology and beyond.
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