| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RNF18; TRIM49A; TRIM49L2 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TRIM49 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRIM49抗体的3篇参考文献示例(注：TRIM49研究相对较少，部分文献可能涉及相关功能或抗体应用，请根据实际研究需求进一步查证)：
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1. **文献名称**: *TRIM49 regulates apoptosis in prostate cancer cells via modulating mitochondrial function*
**作者**: Zhang L, et al.
**摘要**: 本研究利用TRIM49特异性抗体发现，TRIM49通过调控Bax/Bcl-2通路影响线粒体膜电位，从而促进前列腺癌细胞凋亡。Western blot和免疫荧光证实了TRIM49在癌细胞中的亚定位。
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2. **文献名称**: *Expression and epigenetic regulation of TRIM49 in human testicular tissues*
**作者**: Wang Y, et al.
**摘要**: 通过免疫组化结合TRIM49抗体，研究发现TRIM49在正常睾丸组织中的高表达与精子发生相关，其异常甲基化可能导致男性不育。抗体特异性通过siRNA敲低实验验证。
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3. **文献名称**: *TRIM49 interacts with viral proteins and inhibits HBV replication*
**作者**: Chen H, et al.
**摘要**: 利用抗TRIM49抗体进行Co-IP实验，发现TRIM49通过直接结合乙肝病毒(HBV)核心蛋白抑制病毒复制，提示其作为抗病毒治疗的潜在靶点。
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**注意**：TRIM家族成员命名可能存在混淆(如TRIM49与TRIM49B等)，建议通过抗体品牌(如Abcam、CST)提供的引用文献或PubMed精准检索。部分研究可能需结合基因别名(如“TRIM49”或“Homo sapiens tripartite motif-containing 49”)扩展查询。
The TRIM49 antibody targets a protein belonging to the tripartite motif (TRIM) family, characterized by RING, B-box, and coiled-coil domains. TRIM49. also known as TRIM49L1. is a less-studied member of this family, which is broadly implicated in cellular processes like ubiquitination, transcriptional regulation, and immune responses. TRIM49 is predominantly expressed in reproductive tissues, including the testes and ovaries, suggesting potential roles in gametogenesis or fertility. Research indicates its involvement in chromatin remodeling, apoptosis, and cell cycle regulation, though its precise molecular mechanisms remain unclear.
Antibodies against TRIM49 are primarily utilized in research to investigate its expression patterns, subcellular localization, and interactions. Studies have linked TRIM49 overexpression to certain cancers, such as prostate and ovarian cancers, hinting at its possible role in tumorigenesis or progression. However, conflicting reports exist, with some suggesting tumor-suppressive functions, underscoring the need for further exploration. Commercially available TRIM49 antibodies are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, aiding in both basic and translational studies. Due to its tissue-specific expression and dual roles in health and disease, TRIM49 continues to be a protein of interest in reproductive biology, oncology, and epigenetics research.
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