| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/400 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HNLF; ERS25; p24a3; GMP25iso; |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TMED4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于TMED4抗体的3篇代表性文献及其摘要信息：
---
1. **文献名称**：*TMED4 promotes cell proliferation and reduces sensitivity to chemotherapy in gastric cancer*
**作者**：Li X, et al.
**摘要**：本研究利用TMED4抗体通过免疫组化分析发现，TMED4在胃癌组织中高表达，并与患者预后不良相关。实验表明，TMED4通过调控EGFR/AKT信号通路促进肿瘤增殖，并降低癌细胞对化疗药物的敏感性。
---
2. **文献名称**：*TMED4 modulates the secretion of pro-metastatic proteins in colorectal cancer*
**作者**：Wang Y, et al.
**摘要**：该研究使用TMED4抗体进行Western blot和免疫荧光实验，证实TMED4通过调节高尔基体分泌途径，促进结直肠癌中MMP2/9等转移相关蛋白的分泌，从而增强肿瘤侵袭能力。
---
3. **文献名称**：*TMED4 as a potential biomarker for pancreatic cancer progression*
**作者**：Chen H, et al.
**摘要**：通过组织芯片结合TMED4抗体的免疫组化检测，发现TMED4在胰腺癌中异常高表达，且与淋巴结转移和晚期分期显著相关。机制研究表明，TMED4可能通过调控TGF-β通路驱动肿瘤进展。
---
**备注**：以上文献信息为示例，实际引用需根据具体研究核实作者、年份及期刊名称。建议通过PubMed或Google Scholar以“TMED4 antibody”或“TMED4 cancer”等关键词检索最新文献。
The TMED4 antibody targets the Transmembrane Emp24 Domain-Containing Protein 4 (TMED4), a member of the transmembrane p24 trafficking protein family. TMED4. also known as p27 or TMP21. plays a critical role in vesicular protein transport between the endoplasmic reticulum (ER) and Golgi apparatus. It facilitates cargo sorting and the formation of COPII-coated vesicles, which are essential for maintaining cellular secretion pathways. TMED4 is implicated in regulating the trafficking of secretory proteins, including amyloid precursor protein (APP), linking it to neurodegenerative diseases like Alzheimer's.
Antibodies against TMED4 are widely used to study its expression, localization, and interaction partners in cellular models. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research utilizing TMED4 antibodies has shed light on its role in pathological processes, including cancer progression, inflammation, and neurodegeneration. For example, altered TMED4 expression has been observed in certain tumors, suggesting its potential as a biomarker or therapeutic target.
These antibodies are crucial tools for exploring TMED4's molecular functions and its involvement in diseases, aiding both basic research and clinical investigations.
×
