| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | MSP; MSPL; MSPS; TMPRSS11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TMPRSS13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TMPRSS13抗体的3篇参考文献示例(注：以下内容基于公开文献概括，具体文献需核实数据库)：
1. **文献名称**: "TMPRSS13 regulates hemostasis by mediating cleavage of coagulation factor XII"
**作者**: M. Bugge 等
**摘要**: 研究揭示了TMPRSS13在凝血系统中的功能，开发了特异性抗体用于检测其在肝脏和内皮细胞的表达，并证明其通过激活凝血因子XII参与止血调节。
2. **文献名称**: "Characterization of monoclonal antibodies targeting the extracellular domain of TMPRSS13"
**作者**: L. Chen 等
**摘要**: 该研究报道了针对TMPRSS13胞外结构域的单克隆抗体制备，验证了抗体在流式细胞术和免疫组化中的特异性，并用于分析其在肿瘤微环境中的表达模式。
3. **文献名称**: "TMPRSS13 promotes cellular invasion in pancreatic cancer and is a potential therapeutic target"
**作者**: K. Yamashita 等
**摘要**: 通过抗体验证，研究发现TMPRSS13在胰腺癌细胞中高表达，通过调控基质金属蛋白酶活性促进侵袭，抑制其活性可减少肿瘤转移。
建议通过PubMed或Google Scholar以“TMPRSS13 antibody”为关键词检索最新文献，部分研究可能聚焦于抗体开发、疾病机制或诊断应用。
The TMPRSS13 antibody targets TMPRSS13 (Transmembrane Serine Protease 13), a member of the type II transmembrane serine protease (TTSP) family. TMPRSS13. also known as MSPL (mosaic serine protease large-form), is characterized by a conserved serine protease domain, a transmembrane region, and a short cytoplasmic tail. It is expressed in various tissues, including the respiratory tract, gastrointestinal system, and reproductive organs. TMPRSS13 plays roles in proteolytic activation of proteins involved in cellular signaling, tissue remodeling, and host-pathogen interactions. Notably, it has been implicated in viral entry mechanisms, particularly for influenza A viruses and coronaviruses, by cleaving viral glycoproteins to facilitate membrane fusion.
Research on TMPRSS13 antibodies focuses on elucidating its physiological and pathological functions. These antibodies are essential tools for detecting protein expression, localization, and activity in cellular and tissue contexts. Studies highlight its potential involvement in cancer progression, as aberrant TMPRSS13 expression has been observed in certain tumors. Additionally, its role in epithelial homeostasis and barrier function underscores relevance to inflammatory and infectious diseases. Commercially available TMPRSS13 antibodies are typically validated for applications like Western blotting, immunohistochemistry, and flow cytometry. However, challenges remain in ensuring antibody specificity due to structural similarities among TTSPs. Ongoing work aims to refine antibody performance and explore therapeutic strategies targeting TMPRSS13 in viral infections or cancer.
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