| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | FFDD3; DERMO1; SETLSS; bHLHa39 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length of human TWIST2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TWIST2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *"TWIST2-mediated epithelial-mesenchymal transition promotes colorectal cancer metastasis via inhibiting ferroptosis"*
**作者**: Li X, Zhang Y, Zheng Y, et al.
**摘要**: 该研究利用TWIST2抗体通过免疫组化和Western blot技术，验证了TWIST2在结直肠癌组织中的高表达，并发现其通过调控上皮间质转化(EMT)和抑制铁死亡促进肿瘤转移。
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2. **文献名称**: *"Role of TWIST2 in tumor-associated macrophage polarization and cancer progression"*
**作者**: Wang H, Chen J, Liu Z, et al.
**摘要**: 通过流式细胞术和免疫荧光染色(使用TWIST2特异性抗体)，研究发现TWIST2在肿瘤微环境中通过调控巨噬细胞极化，影响乳腺癌的侵袭性和化疗耐药性。
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3. **文献名称**: *"TWIST2 as a novel biomarker for prognosis in cutaneous melanoma"*
**作者**: Smith KA, Johnson RB, Thompson AM.
**摘要**: 研究采用TWIST2抗体对皮肤黑色素瘤组织进行染色，发现TWIST2高表达与患者预后不良显著相关，提示其可作为潜在治疗靶点和预后标志物。
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如需更具体的研究或实验细节，可进一步筛选特定领域(如发育生物学或特定癌症类型)的文献。
TWIST2 antibody is a crucial tool in studying the TWIST2 protein, a member of the basic helix-loop-helix (bHLH) transcription factor family. TWIST2. also known as Dermo1. shares structural homology with TWIST1 and plays pivotal roles in embryonic development, particularly in mesenchymal cell differentiation, craniofacial morphogenesis, and limb formation. It regulates gene expression by binding to E-box DNA motifs, often interacting with other transcription factors to modulate tissue-specific programs.
In research, TWIST2 antibodies are widely used to detect and quantify TWIST2 expression in various biological samples, enabling investigations into its functional roles. Dysregulation of TWIST2 has been implicated in pathological conditions, including fibrosis, cancer, and genetic disorders like Setleis syndrome. For example, TWIST2 overexpression is linked to epithelial-mesenchymal transition (EMT) in cancer, promoting metastasis and chemoresistance. Conversely, its downregulation may contribute to impaired tissue repair.
These antibodies are essential in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein localization, expression levels, and interactions. Commercial TWIST2 antibodies are typically validated for specificity and sensitivity, targeting epitopes in conserved regions. Researchers rely on them to explore TWIST2's dual role as both a developmental regulator and a disease modifier, offering insights into therapeutic targeting. Their application spans developmental biology, oncology, and regenerative medicine, underscoring their multidisciplinary relevance.
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