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Rabbit Polyclonal EIPR1 Antibody

  • 中文名: EIPR1抗体
  • 别    名: TSSC1; EIPR-1
货号: IPDX08916
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesTSSC1; EIPR-1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human EIPR1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于EIPR1抗体的模拟参考文献示例(注:EIPR1相关研究较为有限,以下内容为假设性文献,供参考):

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1. **标题**: *EIPR1 Antibody Characterization and Its Role in Endosomal Trafficking*

**作者**: Smith J, et al.

**摘要**: 本研究开发了一种高特异性兔源多克隆EIPR1抗体,通过免疫印迹和免疫荧光验证其在哺乳动物细胞中对内源性EIPR1蛋白的检测能力。研究发现,EIPR1通过调控内体膜运输参与溶酶体降解途径,抗体阻断实验表明其功能缺失导致内体成熟障碍。

2. **标题**: *EIPR1 Expression in Neurodegenerative Diseases: Insights from Immunohistochemical Analysis*

**作者**: Lee S, et al.

**摘要**: 利用新型小鼠抗人EIPR1单克隆抗体,对阿尔茨海默病模型脑组织进行免疫组化分析。结果显示,EIPR1在病变神经元中的表达显著上调,且与异常蛋白聚集区域共定位,提示其可能作为神经退行性疾病的潜在生物标志物。

3. **标题**: *Structural Insights into EIPR1 Function Using Epitope-Specific Antibodies*

**作者**: Gupta R, et al.

**摘要**: 通过噬菌体展示技术筛选出靶向EIPR1 C端结构域的单链抗体(scFv),结合冷冻电镜解析了EIPR1-抗体复合物结构。研究表明,该结构域对EIPR1与衔接蛋白的相互作用至关重要,抗体干预可抑制其介导的膜融合过程。

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**备注**:若需真实文献,建议通过PubMed或Google Scholar以“EIPR1 antibody”或相关关键词检索,并核实目标蛋白的标准化名称(如HGNC命名)。

背景信息

The EIPR1 (Endosomal Intracompartmental Protein Regulator 1) antibody is a tool used to study the EIPR1 protein, which plays a role in regulating endosomal trafficking and membrane dynamics. EIPR1 is implicated in coordinating vesicle transport between endosomes and the trans-Golgi network, influencing processes like lysosome biogenesis, autophagy, and cargo sorting. Dysregulation of these pathways is linked to neurodegenerative diseases, cancer, and immune disorders. The antibody, typically developed in rabbit or mouse models using immunogenic peptide sequences or recombinant protein fragments, enables detection of EIPR1 in techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Its specificity is validated via knockout cell lines or siRNA-mediated protein depletion. Research utilizing EIPR1 antibodies has highlighted its interaction with components of the HOPS (Homotypic fusion and Protein Sorting) complex and its role in maintaining endolysosomal integrity. Current studies focus on its involvement in pathological conditions, including viral entry mechanisms and metabolic storage diseases. As a reagent, the EIPR1 antibody aids in elucidating molecular mechanisms of intracellular trafficking, offering potential therapeutic insights for trafficking-related disorders.

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