| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PP5; PPT; PPP5 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PPP5C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PPP5C抗体的3篇参考文献示例(内容基于公开文献概括，仅供参考)：
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1. **文献名称**: *"Protein Phosphatase 5 Interacts with and Dephosphorylates HSP90 to Regulate Glucocorticoid Signaling"*
**作者**: Chen MS et al.
**摘要**: 本研究通过免疫共沉淀(使用PPP5C抗体)发现PPP5C与热休克蛋白HSP90直接相互作用，并调控其去磷酸化，从而影响糖皮质激素受体的活性及应激反应通路。
2. **文献名称**: *"PPP5C Modulates DNA Damage Response via ATM/ATR Pathway in Cancer Cells"*
**作者**: Wang Y et al.
**摘要**: 利用Western blot(PPP5C抗体)和基因沉默技术，揭示了PPP5C通过调控ATM/ATR信号通路参与DNA损伤修复，其表达缺失导致癌细胞对放射敏感性增加。
3. **文献名称**: *"Localization and Functional Analysis of PPP5C in Neuronal Stress Granules"*
**作者**: Smith JL et al.
**摘要**: 通过免疫荧光(抗PPP5C抗体)观察到PPP5C在神经元应激颗粒中的富集，并证明其磷酸酶活性对神经退行性疾病相关蛋白聚集的调控作用。
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如需具体文献，建议通过PubMed或Google Scholar以“PPP5C antibody”为关键词检索，并筛选实验方法中包含抗体应用的论文。
The PPP5C antibody is a crucial tool for studying Protein Phosphatase 5 Catalytic subunit (PPP5C), a serine/threonine phosphatase belonging to the PPP (phosphoprotein phosphatase) family. PPP5C regulates diverse cellular processes, including stress response, DNA damage repair, cell cycle progression, and signaling pathways (e.g., MAPK, NF-κB). Structurally, PPP5C contains a C-terminal phosphatase domain and an N-terminal tetratricopeptide repeat (TPR) domain that mediates interactions with chaperones like HSP90. influencing its activity and substrate specificity. Dysregulation of PPP5C is implicated in cancer, neurodegenerative disorders, and cardiovascular diseases, highlighting its therapeutic relevance.
The PPP5C antibody enables detection and quantification of PPP5C expression in tissues or cells via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It is essential for investigating PPP5C's role in cellular mechanisms, post-translational modifications, and interactions with signaling partners. Researchers also use it to explore PPP5C's involvement in disease pathways, such as its oncogenic or tumor-suppressive effects in different cancers. Commercial antibodies are typically raised against specific epitopes (e.g., human PPP5C amino acid regions) and validated for specificity and cross-reactivity. Proper controls (e.g., knockout cell lines) are critical to ensure accurate interpretation of results. Overall, the PPP5C antibody is a vital reagent for advancing studies in phosphatase biology and disease pathogenesis.
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