| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | UGT2; HUGT2; UGCGL2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UGGT2抗体的3篇参考文献(文献标题、作者及摘要内容简要概括)：
1. **"Characterization of UGGT2-Specific Antibodies for Studying Glycoprotein Quality Control in the ER"**
*作者：Smith A, et al.*
**摘要**：本研究开发并验证了针对UGGT2的高度特异性多克隆抗体，证实其在Western blot和免疫荧光中的适用性，用于监测内质网中未折叠糖蛋白的再葡萄糖基化过程。
2. **"Role of UGGT2 in Collagen Biosynthesis Revealed by Antibody-Based Inhibition Assays"**
*作者：Tanaka K, et al.*
**摘要**：通过UGGT2特异性抗体阻断实验，发现UGGT2在胶原蛋白IV的正确折叠和分泌中起关键作用，抗体应用为研究胶原相关疾病提供了工具。
3. **"Development of a Monoclonal Antibody Panel for ER Glycoprotein Remodeling Enzymes"**
*作者：Lee J, et al.*
**摘要**：文章报道了一种新型抗UGGT2单克隆抗体的制备，该抗体能特异性识别UGGT2的C端结构域，成功应用于组织切片中UGGT2的定位及与UGGT1的功能差异分析。
注：以上文献信息为示例性内容，实际文献需通过PubMed或Web of Science等平台检索确认。建议使用关键词“UGGT2 antibody”或“UGG2T immunological tools”查找最新研究。
UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2) is an endoplasmic reticulum (ER)-resident enzyme critical for quality control of N-linked glycoproteins. It acts as a key sensor in the ER-associated degradation (ERAD) pathway, selectively recognizing misfolded or incompletely folded glycoproteins. UGGT2 re-glucosylates exposed hydrophobic regions on these proteins, tagging them with a glucose residue to facilitate rebinding to calnexin/calreticulin chaperones for refolding attempts. If proper folding isn’t achieved, the protein is ultimately targeted for proteasomal degradation.
Antibodies against UGGT2 are essential tools for studying its expression, localization, and role in protein quality control mechanisms. They are widely used in Western blotting, immunofluorescence, and immunohistochemistry to investigate UGGT2's involvement in diseases linked to ER stress, such as neurodegenerative disorders, cancer, and metabolic syndromes. UGGT2-specific antibodies help distinguish it from its isoform UGGT1. which shares structural similarities but exhibits differences in substrate specificity and tissue distribution. Researchers also utilize these antibodies to explore UGGT2's interactions with other ERAD components or its dysregulation under pathological conditions, including viral infections and inflammatory responses. Validating antibody specificity is crucial due to sequence homology among glycosyltransferase family members. High-quality UGGT2 antibodies enable insights into cellular stress responses and potential therapeutic targets for protein-misfolding diseases.
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