Rabbit Polyclonal UBAP2L Antibody

The UBAP2L (Ubiquitin-associated protein 2-like) antibody is a tool used to study the UBAP2L protein, a conserved eukaryotic protein implicated in multiple cellular processes. Structurally, UBAP2L contains a ubiquitin-associated (UBA) domain and a proline-rich region, suggesting roles in ubiquitin signaling and protein interactions. Functionally, it interacts with components of the endosomal sorting complex required for transport (ESCRT), regulating endosomal trafficking, autophagy, and lysosomal degradation. Studies link UBAP2L to cancer progression, where its overexpression enhances cell proliferation, migration, and chemoresistance in malignancies like breast cancer and glioblastoma. It may act as an oncogene by stabilizing mRNA targets through interactions with stress granules or modulating signaling pathways like mTOR. Additionally, UBAP2L has been associated with neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), potentially due to its role in protein aggregation clearance. The antibody, typically developed in rabbit or mouse hosts, enables detection of UBAP2L expression and localization via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Its application advances research into UBAP2L's molecular mechanisms, disease associations, and therapeutic targeting. Validation remains critical, as off-target effects may arise from homology with other UBA-domain proteins.