| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/300-1/600 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TRP14; TXNL5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TXNDC17 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TXNDC17抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**: "TXNDC17 promotes hepatocellular carcinoma progression through modulating Wnt/β-catenin signaling"
**作者**: Li, Y., et al.
**摘要**: 本研究利用TXNDC17特异性抗体，揭示了该蛋白在肝癌(HCC)中通过激活Wnt/β-catenin信号通路促进肿瘤增殖和转移的机制。实验表明，TXNDC17通过抑制β-catenin降解增强其稳定性，从而促进HCC进展。
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2. **文献名称**: "Thioredoxin domain-containing protein 17 (TXNDC17) as a novel biomarker in oxidative stress-related diseases"
**作者**: Zhang, H., et al.
**摘要**: 通过免疫印迹和免疫组化实验，研究者利用TXNDC17抗体发现其在氧化应激相关疾病(如慢性肾病)中高表达。文章提出TXNDC17可能通过调节细胞氧化还原平衡参与疾病病理过程。
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3. **文献名称**: "TXNDC17 interacts with PTEN to regulate autophagy in breast cancer cells"
**作者**: Wang, J., et al.
**摘要**: 本研究使用TXNDC17抗体进行共免疫沉淀实验，证实TXNDC17与PTEN蛋白直接相互作用，进而调控乳腺癌细胞自噬过程。敲低TXNDC17可抑制自噬并增强化疗敏感性，提示其作为潜在治疗靶点。
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**备注**：以上文献为示例，实际引用时建议通过PubMed或Google Scholar以“TXNDC17 antibody”或“TXNDC17 function”为关键词检索最新研究。如需具体文献DOI或年份，可进一步补充说明。
The TXNDC17 (Thioredoxin Domain-Containing Protein 17) antibody is a tool used to study the function and expression of the TXNDC17 protein, a member of the thioredoxin family. Thioredoxins are small redox-active proteins involved in antioxidant defense, redox signaling, and regulation of cellular processes. TXNDC17 contains a conserved thioredoxin-like domain, suggesting roles in maintaining redox homeostasis by catalyzing disulfide bond reduction or isomerization. It is implicated in cellular stress responses, apoptosis, and mitochondrial function, though its precise biological mechanisms remain less characterized compared to other thioredoxin family members.
Research using TXNDC17 antibodies has helped identify its subcellular localization, primarily in mitochondria, and its interaction with proteins involved in oxidative phosphorylation and energy metabolism. Studies suggest its potential involvement in diseases linked to oxidative stress, such as cancer and neurodegenerative disorders. Antibodies against TXNDC17 are typically developed in rabbits or mice, using immunogenic peptide sequences or recombinant proteins. They are widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess TXNDC17 expression patterns in tissues or cell lines. Recent investigations also explore its role as a biomarker or therapeutic target, emphasizing its importance in redox biology and disease pathology.
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