Rabbit Polyclonal UBLCP1 Antibody

The UBLCP1 (Ubiquitin-like domain-containing CTD phosphatase 1) antibody is a tool used to study the UBLCP1 protein, a phosphatase implicated in regulating proteasome activity and cellular protein homeostasis. UBLCP1 contains a ubiquitin-like (UBL) domain and a C-terminal domain (CTD) phosphatase motif, which enables its interaction with the 19S regulatory particle of the 26S proteasome. Research suggests UBLCP1 dephosphorylates specific subunits of the proteasome, potentially modulating its assembly, localization, or activity under stress conditions. This protein is thought to play a role in linking proteasomal degradation to cellular stress responses, including endoplasmic reticulum (ER) stress and nutrient deprivation. Antibodies targeting UBLCP1 are utilized in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, subcellular distribution, and interaction partners. Studies involving UBLCP1 antibodies have provided insights into diseases associated with proteasomal dysregulation, such as neurodegenerative disorders and cancers. The antibody's specificity is often validated via knockout controls or siRNA-mediated silencing. Understanding UBLCP1's function through such antibodies may reveal therapeutic targets for conditions linked to impaired protein degradation pathways.