Rabbit Polyclonal UBAP1 Antibody

The UBAP1 (Ubiquitin-associated protein 1) antibody targets a protein involved in ubiquitin-dependent processes, particularly within the endosomal sorting complex required for transport (ESCRT) system. UBAP1 is a key subunit of ESCRT-I, facilitating the sorting of ubiquitinated cargo proteins into multivesicular bodies (MVBs) for lysosomal degradation or extracellular secretion. Structurally, it contains a UBA domain for ubiquitin binding and a SUI1 domain critical for ESCRT-I assembly. Dysregulation of UBAP1 is linked to disrupted protein homeostasis, impacting cellular processes like receptor trafficking, viral budding, and autophagy. Research highlights its role in cancer, where altered UBAP1 expression correlates with tumor progression, metastasis, and drug resistance. Additionally, UBAP1 mutations are associated with hereditary spastic paraplegia (HSP), a neurodegenerative disorder, underscoring its importance in neuronal health. The UBAP1 antibody is widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interaction partners in both physiological and disease contexts. It serves as a vital tool for exploring ESCRT-mediated mechanisms and developing therapeutic strategies for UBAP1-related pathologies.