| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于VASH2抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**: *"Vasohibin-2 modulates tumor progression in hematopoietic malignancies through angiogenesis regulation"*
**作者**: Sato Y, et al.
**摘要**: 该研究开发了特异性VASH2抗体，用于检测其在白血病和淋巴瘤中的表达。研究发现，VASH2通过促进肿瘤血管生成和微环境重塑，加速恶性肿瘤进展，提示其作为治疗靶点的潜力。
2. **文献名称**: *"High expression of Vasohibin-2 is correlated with poor prognosis in hepatocellular carcinoma"*
**作者**: Zhang L, et al.
**摘要**: 通过免疫组化(使用VASH2抗体)分析肝癌组织样本，发现VASH2高表达与肿瘤转移和患者生存率降低显著相关，表明其可作为肝癌预后标志物。
3. **文献名称**: *"VASH2 promotes epithelial-mesenchymal transition and metastasis via TGF-β signaling in colorectal cancer"*
**作者**: Hosaka K, et al.
**摘要**: 利用VASH2抗体进行蛋白定位和功能研究，揭示VASH2通过激活TGF-β信号通路促进结直肠癌的EMT和远处转移，为靶向治疗提供依据。
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这些文献均涉及VASH2抗体的实验应用，涵盖基础机制、临床预后及转移机制研究。如需具体文章，建议通过PubMed或Google Scholar按作者及关键词检索。
Vasohibin-2 (VASH2) is a member of the vasohibin protein family, initially identified as a regulator of angiogenesis. Unlike its homolog VASH1. which primarily inhibits angiogenesis, VASH2 is implicated in promoting blood vessel formation, particularly in pathological conditions such as cancer. It is expressed in endothelial cells, certain immune cells, and various tumor tissues. VASH2 modulates microtubule dynamics by interacting with small vasohibin-binding protein (SVBP), facilitating microtubule detyrosination—a post-translational modification critical for cellular motility and invasion. This activity links VASH2 to tumor progression, metastasis, and resistance to anti-angiogenic therapies.
VASH2 antibodies are immunological tools used to detect and study the expression, localization, and function of VASH2 in research settings. They are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate VASH2's role in diseases, especially cancers. Studies suggest that elevated VASH2 levels correlate with poor prognosis in malignancies, including hepatocellular carcinoma and glioblastoma, making it a potential therapeutic target. However, its dual roles in physiological and pathological angiogenesis remain under investigation. Commercially available VASH2 antibodies are typically validated for specificity against human, mouse, or rat isoforms, aiding mechanistic studies of vascular biology and tumor microenvironment interactions.
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