Rabbit Polyclonal CHMP3 Antibody

CHMP3 (Charged Multivesicular Body Protein 3), a component of the ESCRT-III (Endosomal Sorting Complex Required for Transport III) complex, plays a critical role in membrane remodeling processes such as multivesicular body formation, viral budding, cytokinesis, and membrane repair. It functions in concert with other ESCRT subunits to facilitate the sorting and trafficking of ubiquitinated cargoes into intralumenal vesicles of late endosomes, as well as the scission of membrane necks during abscission or pathogen release. CHMP3 antibodies are essential tools for studying these mechanisms, enabling researchers to detect protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of CHMP3 has been linked to various diseases, including cancer, neurodegenerative disorders, and impaired antiviral responses, making it a target for therapeutic exploration. Antibodies specific to CHMP3 help elucidate its role in ESCRT-dependent pathways, viral replication (e.g., HIV-1 budding), and cellular stress responses. They also aid in investigating CHMP3’s non-canonical functions, such as its potential involvement in autophagy and inflammation. Validation of these antibodies across species and applications ensures their utility in both basic research and translational studies.