Rabbit Polyclonal WSB1 Antibody

The WSB1 (WD repeat and SOCS box-containing protein 1) antibody is a research tool used to study the WSB1 protein, a key component of the ubiquitin-proteasome system. WSB1 functions as an E3 ubiquitin ligase adaptor, facilitating substrate recognition and degradation via the 26S proteasome. It contains WD40 repeats for protein-protein interactions and a SOCS box domain that recruits Elongin B/C-Cullin complexes to form an active E3 ligase. WSB1 is implicated in diverse cellular processes, including hypoxia response, circadian rhythm regulation, and protein quality control. Notably, it interacts with hypoxia-inducible factor 1α (HIF-1α), promoting its ubiquitination and degradation under normoxic conditions, thereby influencing tumor progression and angiogenesis. Dysregulation of WSB1 has been linked to cancers, neurodegenerative disorders, and inflammatory diseases. Antibodies targeting WSB1 are essential for detecting its expression, localization, and interactions in experimental models. They are widely used in techniques like Western blotting, immunoprecipitation, and immunohistochemistry. Researchers also employ WSB1 antibodies to explore its role as a potential therapeutic target or biomarker, particularly in conditions involving proteostasis imbalance or hypoxic stress. Validation of antibody specificity through knockout controls remains critical due to structural similarities among SOCS box-containing proteins.