Rabbit Polyclonal CCN6 Antibody

The CCN6 antibody is a tool used to detect CCN6. a secreted protein encoded by the WISP3 gene, belonging to the CCN family (Cellular Communication Network Factors). CCN6 plays critical roles in regulating cell proliferation, differentiation, adhesion, and extracellular matrix remodeling. It is implicated in skeletal development, joint homeostasis, and tumorigenesis. Mutations in WISP3 are linked to progressive pseudorheumatoid dysplasia (PPDH), a rare genetic disorder causing cartilage degeneration. In cancer, CCN6 exhibits context-dependent roles, acting as a tumor suppressor in some malignancies (e.g., breast cancer) while promoting aggressiveness in others (e.g., pancreatic cancer). Antibodies targeting CCN6 are essential for research to elucidate its expression patterns, interactions, and mechanisms in both physiological and pathological settings. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study CCN6's localization, regulation, and potential as a biomarker or therapeutic target. Recent studies also explore its involvement in fibrosis and metabolic diseases, expanding its biomedical relevance.