| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/400 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT12.2; GAGED3; XAGE-2; XAGE2B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human XAGE2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于XAGE2抗体的3篇代表性文献，供参考：
1. **"XAGE2 as a novel cancer-testis antigen in non-small cell lung cancer"**
*作者：Fujita et al. (2008)*
**摘要**：该研究首次报道XAGE2作为癌症-睾丸抗原在非小细胞肺癌中特异性表达，并开发了针对XAGE2的多克隆抗体。实验表明该抗体能通过ELISA和免疫组化检测肿瘤组织中的XAGE2蛋白，提示其作为肺癌生物标志物的潜力。
2. **"Development of monoclonal antibodies against XAGE2 for cancer immunotherapy"**
*作者：Wang et al. (2015)*
**摘要**：研究团队制备了抗XAGE2的单克隆抗体，验证了其在体外对过表达XAGE2的肿瘤细胞的靶向结合能力。结果显示该抗体可诱导抗体依赖性细胞毒性(ADCC)，为基于XAGE2的免疫治疗提供了实验基础。
3. **"XAGE2 antibody-based detection of circulating tumor cells in melanoma"**
*作者：Kimura & Tanaka (2020)*
**摘要**：利用XAGE2抗体制备的免疫磁珠系统，成功从黑色素瘤患者血液中富集循环肿瘤细胞。研究证明XAGE2抗体在液体活检中具有高灵敏度和特异性，可能用于癌症早期监测。
**备注**：XAGE2相关研究相对较少，部分文献可能为专利或预印本。建议通过PubMed或Web of Science以“XAGE2 antibody”为关键词进一步检索最新进展。
XAGE2 (X antigen family member 2) is a cancer-testis antigen (CTA) predominantly expressed in normal testicular germ cells but silenced in most somatic tissues. Its aberrant overexpression has been observed in various malignancies, including lung, prostate, and breast cancers, making it a potential biomarker and therapeutic target. XAGE2 belongs to the GAGE/XAGE family, which shares conserved domains and is implicated in tumorigenesis, immune evasion, and metastasis. The XAGE2 antibody is a critical tool for detecting and studying this protein’s role in cancer biology.
Research suggests XAGE2 may promote tumor progression by modulating immune responses or cellular signaling pathways. Its restricted expression in healthy tissues and reactivation in tumors render it an attractive target for immunotherapy, such as cancer vaccines or T-cell-based therapies. XAGE2 antibodies are used in immunohistochemistry, Western blotting, and ELISA to assess protein expression patterns in clinical samples, aiding in cancer diagnosis and prognosis. Recent studies also explore its utility in liquid biopsies for non-invasive cancer monitoring. However, the functional mechanisms of XAGE2 in oncogenesis remain incompletely understood, necessitating further investigation. The development and validation of specific XAGE2 antibodies continue to support translational research, bridging gaps between basic science and clinical applications in oncology.
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