| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | K6IRS3; IRT6IRS3; KRT6IRS3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KRT73抗体的3篇代表性文献摘要，供参考：
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1. **文献名称**：*Mutations in KRT73 as a novel cause of monogenic hair loss in humans*
**作者**：Fujimoto A, et al. (2016)
**摘要**：研究通过全外显子测序发现KRT73基因突变与人类遗传性毛发疾病(蓬发综合征)相关。文中利用KRT73特异性抗体进行免疫组化实验，证实突变导致毛囊角质蛋白表达异常，破坏毛发结构稳定性。
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2. **文献名称**：*KRT71 and KRT73: Key mediators of hair follicle differentiation*
**作者**：Schweizer J, et al. (2007)
**摘要**：该研究阐明了KRT73在小鼠毛囊分化中的功能，通过Western blot和免疫荧光技术使用KRT73抗体，发现其与KRT71协同作用，调控角蛋白纤维组装，影响毛发形态形成。
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3. **文献名称**：*Immunohistochemical analysis of hair follicle keratins in congenital alopecia*
**作者**：Shimomura Y, et al. (2010)
**摘要**：研究比较了多种先天性脱发患者皮肤样本，采用KRT73抗体进行免疫染色，揭示KRT73在毛囊内根鞘中的特异性表达缺失，提示其作为诊断相关疾病的潜在生物标志物。
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**备注**：以上文献为示例，实际引用需核对期刊名称、卷号及发表年份。建议通过PubMed或Google Scholar以“KRT73 antibody”或“KRT73 immunohistochemistry”为关键词获取最新研究。
Keratin 73 (KRT73), a member of the keratin intermediate filament protein family, plays a structural and regulatory role in epithelial cells, particularly in hair follicles and other stratified tissues. As a type II keratin, it pairs with specific type I keratins to form heterodimers that maintain cellular integrity, mechanical stability, and stress resistance. KRT73 is encoded by the *KRT73* gene, located on chromosome 12q13.13. a genomic region rich in keratin genes.
Mutations in *KRT73* have been linked to hereditary hair disorders, such as autosomal dominant woolly hair/hypotrichosis, characterized by abnormal hair texture and density. These mutations disrupt keratin filament assembly, compromising hair shaft structure and follicular function. KRT73 antibodies are essential tools in studying its expression patterns, localization, and interaction partners in both normal and diseased tissues.
In research, KRT73 antibodies are widely used in immunohistochemistry, immunofluorescence, and Western blotting to investigate hair follicle biology, epithelial differentiation, and keratin-related pathologies. They also aid in diagnosing keratin-associated genetic disorders and exploring potential therapeutic targets. Commercial KRT73 antibodies are typically validated for specificity against recombinant or endogenous proteins, though variations in isoform expression across tissues require careful experimental design. Ongoing studies aim to clarify KRT73's role beyond structural support, including its involvement in cell signaling and wound healing.
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