| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FXNA; KIAA1815; bA207C16.3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ERMP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ERMP1抗体的3篇参考文献示例(注：由于ERMP1相关研究较少，部分文献可能涉及功能或抗体应用，以下为模拟示例)：
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1. **文献名称**：*ERMP1 is a novel regulator of ER-associated degradation in mammalian cells*
**作者**：Smith A, et al.
**摘要**：本研究鉴定了ERMP1作为内质网相关降解(ERAD)通路的关键调控因子。通过使用特异性ERMP1抗体进行免疫沉淀和免疫荧光，作者发现ERMP1与Hrd1复合物相互作用，并调控错误折叠蛋白的降解。抗体验证显示其在小鼠和人类细胞中具有高特异性。
2. **文献名称**：*Development of a monoclonal antibody against ERMP1 for cancer biomarker studies*
**作者**：Tanaka K, et al.
**摘要**：该研究报道了一种新型抗ERMP1单克隆抗体的开发，并通过ELISA、Western blot验证其特异性。研究发现，ERMP1在结直肠癌组织中高表达，提示其作为潜在生物标志物的可能性。抗体成功应用于组织微阵列的免疫组化分析。
3. **文献名称**：*ERMP1 deficiency disrupts lipid metabolism in the endoplasmic reticulum*
**作者**：Chen L, et al.
**摘要**：利用CRISPR-Cas9敲除细胞模型和ERMP1抗体进行蛋白定位分析，作者发现ERMP1缺失导致内质网脂质代谢异常，并激活未折叠蛋白反应(UPR)。抗体在亚细胞分级实验中被用于确认ERMP1的定位。
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**备注**：
- ERMP1(Endoplasmic Reticulum MetalloProtease 1)相关研究较少，实际文献可能需要结合具体数据库检索。
- 若需真实文献，建议通过PubMed或Google Scholar以关键词“ERMP1 antibody”或“ERMP1 function”检索，并筛选涉及抗体开发或应用的论文。
The ERMP1 (Endoplasmic Reticulum Metalloendopeptidase 1) antibody is a tool used to study the ERMP1 protein, a zinc-dependent metalloprotease localized to the endoplasmic reticulum (ER). ERMP1. also known as EROP1 or PRSM1. plays a role in ER-associated degradation (ERAD), a critical quality control pathway that identifies and degrades misfolded proteins within the ER. It is implicated in cleaving terminal hydrophobic residues from ERAD substrates, facilitating their retrotranslocation to the cytoplasm for proteasomal degradation. Dysregulation of ERMP1 has been linked to ER stress-related pathologies, including neurodegenerative diseases and cancer.
ERMP1 antibodies are primarily utilized in research to detect and quantify ERMP1 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in exploring ERMP1's function in cellular proteostasis, stress responses, and disease mechanisms. Recent studies highlight its potential as a biomarker in certain cancers, where altered expression correlates with tumor progression or therapeutic resistance. Both monoclonal and polyclonal ERMP1 antibodies are available, with specificity validated across human and model organisms. As ERMP1's biological roles remain under active investigation, these antibodies are essential for elucidating its contributions to ER homeostasis and disease pathways.
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