| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999 |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MAT2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAT2B抗体的3篇参考文献示例(内容为模拟生成，非真实文献)：
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1. **文献名称**: "MAT2B Expression in Hepatocellular Carcinoma: Prognostic Implications and Role in Methionine Metabolism"
**作者**: Zhang, L. et al.
**摘要**: 本研究通过免疫组化(使用MAT2B特异性抗体)分析了MAT2B在肝癌组织中的表达，发现其高表达与患者生存率降低显著相关。进一步实验表明，MAT2B通过调控甲硫氨酸代谢通路促进肿瘤细胞增殖。
2. **文献名称**: "Regulation of MAT2B by miR-21 in Colorectal Cancer Cells"
**作者**: Wang, Y. et al.
**摘要**: 文章利用MAT2B抗体进行Western blot和免疫荧光实验，证实miR-21通过靶向抑制MAT2B表达影响结直肠癌细胞甲基化代谢，进而抑制凋亡并增强化疗耐药性。
3. **文献名称**: "Development and Validation of a Novel MAT2B Monoclonal Antibody for Functional Studies"
**作者**: Smith, J.R. et al.
**摘要**: 该研究报道了一种高特异性MAT2B单克隆抗体的开发，验证了其在ELISA、流式细胞术及组织芯片中的适用性，并发现MAT2B在多种癌细胞系中与MAT2A形成功能性复合物。
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**注**: 以上文献为示例，实际引用时请通过PubMed、Web of Science等平台检索真实文献。若需具体文献协助，可提供更多关键词或研究场景。
The MAT2B antibody is designed to detect methionine adenosyltransferase 2β (MAT2B), a regulatory subunit of the enzyme methionine adenosyltransferase II (MAT II). MAT II catalyzes the synthesis of S-adenosylmethionine (SAMe), a universal methyl donor critical for cellular methylation reactions, including DNA, protein, and lipid modifications. MAT2B exists in two splice variants (V1 and V2) and plays a key role in modulating MAT II activity and SAMe levels, particularly in proliferating cells. Dysregulation of MAT2B has been linked to metabolic disorders, liver diseases, and cancers, where its overexpression may promote cell proliferation, survival, and chemoresistance by influencing SAMe-dependent pathways and interacting with signaling molecules like HuR and β-catenin.
MAT2B antibodies are widely used in research to study MAT2B expression, localization, and function in various tissues and disease models. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These tools help elucidate MAT2B’s role in cellular processes, including redox regulation, apoptosis, and epigenetic modulation, offering insights into its potential as a therapeutic target. Researchers also explore its association with conditions like hepatocellular carcinoma, Alzheimer’s disease, and diabetes, where SAMe metabolism imbalances contribute to pathogenesis.
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