| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GXII; ROSSY; PLA2G12 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PLA2G12A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PLA2G12A抗体的3篇参考文献的简要整理(基于现有研究推测内容，仅供参考)：
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1. **标题**：*PLA2G12A regulates hepatitis C virus infection by modulating lipoprotein secretion*
**作者**：Sandra C. Chothe, Susan L. Uprichard 等
**摘要**：研究揭示了PLA2G12A在丙型肝炎病毒(HCV)感染中的作用，发现其通过调控脂蛋白分泌影响病毒颗粒的形成。研究使用了特异性PLA2G12A抗体验证蛋白表达，表明该酶可能成为抗病毒治疗靶点。
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2. **标题**：*Secreted phospholipase A2 group XIIA modulates insulin secretion and glucose homeostasis*
**作者**：Yuji Matsuzawa, Tohru Funahashi 等
**摘要**：通过PLA2G12A抗体进行蛋白检测，发现该酶在胰岛β细胞中高表达，并参与胰岛素分泌调控。基因敲除小鼠模型显示其缺失导致糖代谢异常，提示其与糖尿病病理相关。
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3. **标题**：*Characterization of a monoclonal antibody against human PLA2G12A for immunohistochemical applications*
**作者**：Hiroshi Sato, Kazuhiko Ishihara 等
**摘要**：报道了一种针对人PLA2G12A的单克隆抗体的开发与验证，证明其在组织切片中的特异性染色能力。该抗体成功应用于肝癌和动脉粥样硬化样本中PLA2G12A的定位分析。
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**说明**：以上文献信息为模拟示例，实际文献需通过PubMed、Web of Science等平台以关键词“PLA2G12A antibody”或“anti-PLA2G12A”检索获取。建议结合具体研究方向筛选近年高质量论文。
**Background of PLA2G12A Antibody**
Phospholipase A2 Group XIIA (PLA2G12A) is a secreted enzyme belonging to the phospholipase A2 superfamily, which hydrolyzes phospholipids to generate fatty acids and lysophospholipids. PLA2G12A is distinct from other PLA2 members due to its unique structural features, including 12 conserved disulfide bonds and a divergent catalytic site, suggesting specialized roles in lipid metabolism and signaling. It is primarily expressed in the liver and has been implicated in regulating lipoprotein homeostasis, particularly high-density lipoprotein (HDL) and low-density lipoprotein (LDL) metabolism, linking it to cardiovascular diseases and metabolic disorders.
PLA2G12A antibodies are tools developed to detect and study the expression, localization, and function of this enzyme. These antibodies enable researchers to investigate PLA2G12A's involvement in pathological processes, such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD), and viral infections (e.g., hepatitis C), where PLA2G12A may modulate host-pathogen interactions. Additionally, PLA2G12A antibodies are used in diagnostic research to assess protein levels in clinical samples, aiding biomarker discovery. Their applications extend to mechanistic studies, including blocking enzymatic activity or disrupting protein-protein interactions to explore therapeutic targeting. Recent studies also highlight PLA2G12A's potential role in cancer progression, making these antibodies valuable in oncology research. Overall, PLA2G12A antibodies serve as critical reagents for unraveling the enzyme's biological significance and translational potential.
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