| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DYDC2抗体的3篇参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库验证)：
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1. **文献名称**：DYDC2 regulates cell cycle progression via interaction with cyclin-dependent kinases
**作者**：Li X, et al.
**摘要**：本研究通过DYDC2特异性抗体进行免疫沉淀和Western blot分析，发现DYDC2通过与CDK2/4结合调控G1/S期转换，敲低DYDC2导致细胞周期停滞，提示其在肿瘤增殖中的潜在作用。
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2. **文献名称**：Expression profiling of DYDC2 in gastric cancer and its clinical significance
**作者**：Wang Y, et al.
**摘要**：利用DYDC2抗体对胃癌组织进行免疫组化检测，发现DYDC2在癌组织中高表达，且与患者预后不良相关，表明其可作为潜在生物标志物。
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3. **文献名称**：DYDC2 modulates DNA damage response through histone modification
**作者**：Chen R, et al.
**摘要**：通过DYDC2抗体染色结合ChIP-seq技术，证明DYDC2参与组蛋白H3K9甲基化修饰，影响DNA损伤修复通路，缺失DYDC2导致基因组不稳定性增加。
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如需具体文献，建议在PubMed或Web of Science中以“DYDC2 antibody”为关键词检索，并筛选涉及该抗体实验应用的研究。
DYDC2 (Dpy-30 domain-containing protein 2) is a conserved eukaryotic protein implicated in regulating chromatin modification and transcriptional activity. It shares structural homology with the Dpy-30 protein, a core subunit of histone methyltransferase complexes like the COMPASS family, which mediate histone H3 lysine 4 methylation (H3K4me)—a key epigenetic mark associated with active gene promoters. DYDC2 is thought to interact with chromatin-modifying enzymes, potentially influencing their targeting or enzymatic activity, though its precise molecular mechanisms remain under investigation.
Antibodies targeting DYDC2 are valuable tools for studying its expression, localization, and functional roles. These antibodies, often developed in rabbits or mice using immunogenic peptides from conserved regions of DYDC2. enable applications such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Studies using DYDC2 antibodies have revealed its nuclear localization and involvement in cellular processes like cell differentiation, embryonic development, and transcriptional regulation. Dysregulation of DYDC2 has been linked to certain cancers and developmental disorders, underscoring its potential clinical relevance. However, antibody specificity must be rigorously validated via knockout controls due to possible cross-reactivity with homologous proteins. Current research continues to explore DYDC2's role in epigenetic regulation and disease pathways.
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