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Rabbit Polyclonal DHDH Antibody

  • 中文名: DHDH抗体
  • 别    名: 2DD; HUM2DD
货号: IPDX09143
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

Aliases2DD; HUM2DD
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于DHDH抗体的虚构参考文献示例(仅供示例用途,非真实文献):

1. **文献名称**:*DHDH Antibody as a Novel Biomarker for Early Detection of Hepatocellular Carcinoma*

**作者**:Li, X. et al.

**摘要**:本研究验证了DHDH抗体在肝细胞癌(HCC)患者血清中的高特异性表达,通过ELISA和免疫组化分析,发现其敏感度优于传统标志物AFP,提示其作为早期诊断工具的潜力。

2. **文献名称**:*Functional Characterization of DHDH in Lipid Metabolism Using Polyclonal Antibodies*

**作者**:Wang, Y. & Zhang, R.

**摘要**:通过制备兔源多克隆DHDH抗体,研究揭示了DHDH蛋白在脂肪酸氧化中的调控作用,并发现其缺失导致小鼠模型出现脂质代谢紊乱。

3. **文献名称**:*DHDH Autoantibodies in Autoimmune Hepatitis: Clinical Correlations*

**作者**:Gupta, S. et al.

**摘要**:该研究在自身免疫性肝炎患者中检测到DHDH自身抗体,其滴度与疾病活动度呈正相关,提示其可能参与肝细胞免疫损伤机制。

4. **文献名称**:*Development of a High-Affinity Monoclonal DHDH Antibody for Targeted Therapy*

**作者**:Chen, L. et al.

**摘要**:团队开发了一种靶向DHDH的单克隆抗体,体外实验显示其可抑制肿瘤细胞增殖,并在小鼠模型中显著减少转移灶形成。

注:以上内容为模拟创作,实际文献需通过学术数据库检索确认。

背景信息

The DHDH (dihydrodiol dehydrogenase) antibody is a research tool targeting the DHDH enzyme, a member of the aldo-keto reductase superfamily. DHDH catalyzes the NAD(P)H-dependent oxidation of dihydrodiols, playing roles in xenobiotic metabolism, steroid biosynthesis, and detoxification pathways. It is implicated in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs), linking it to studies on carcinogenesis and environmental toxin processing. DHDH antibodies are primarily used to detect and quantify the enzyme's expression in tissues or cells via techniques like Western blotting, immunohistochemistry, or immunofluorescence. These antibodies aid in exploring DHDH's tissue-specific distribution, regulatory mechanisms, and potential associations with diseases, including cancer and metabolic disorders. Most commercial DHDH antibodies are raised in rabbits or mice using recombinant protein immunogens, with validation focusing on specificity and cross-reactivity controls. Recent studies investigate DHDH's role in drug resistance and its interaction with chemotherapeutic agents, highlighting its therapeutic relevance. However, challenges persist in distinguishing DHDH isoforms due to high sequence homology within the enzyme family. Ongoing research aims to clarify its pathophysiological functions and diagnostic potential.

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