| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TNC; TN-C; TNNC; CMD1Z; CMH13 |
| WB Predicted band size | 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TNNC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TNNC1抗体的参考文献示例(注：以下内容为模拟文献，非真实存在，仅供格式参考)：
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1. **文献名称**: *Development of a Monoclonal Antibody for Specific Detection of TNNC1 in Cardiac Tissue*
**作者**: Smith A, et al.
**摘要**: 该研究开发了一种针对心脏肌钙蛋白C(TNNC1)的单克隆抗体，验证了其在人类和小鼠心肌组织中的特异性。抗体通过免疫组化和Western blot证实了其在心肌肥大模型中TNNC1表达水平变化的检测能力。
2. **文献名称**: *TNNC1 Mutations and Antibody-Based Detection in Hypertrophic Cardiomyopathy*
**作者**: Jones B, et al.
**摘要**: 研究利用TNNC1抗体分析了遗传性肥厚型心肌病(HCM)患者的基因突变与蛋白表达的关系，发现特定突变会导致TNNC1稳定性降低，抗体检测为临床病理机制提供了依据。
3. **文献名称**: *Comparative Analysis of TNNC1 Antibodies in Diagnostic Applications*
**作者**: Brown C, et al.
**摘要**: 对比了多种市售TNNC1抗体的灵敏度和特异性，提出优化方案以提高心肌活检样本中低丰度TNNC1的检测准确性，并验证了其在心脏疾病诊断中的潜在价值。
4. **文献名称**: *TNNC1 Localization in Cardiomyocytes Using Immunofluorescence*
**作者**: Lee D, et al.
**摘要**: 通过高分辨率免疫荧光技术结合TNNC1抗体，揭示了TNNC1在心肌细胞收缩单元中的动态分布，为研究心脏收缩功能障碍提供了新方法。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“TNNC1 antibody”或“cardiac troponin C antibody”获取最新研究。
TNNC1 (Troponin C, slow skeletal and cardiac muscle) is a calcium-binding protein critical for regulating muscle contraction in cardiac and slow-twitch skeletal muscles. As a subunit of the troponin complex, TNNC1 binds Ca²⁺ ions during excitation-contraction coupling, inducing conformational changes that allow myosin-actin interaction. TNNC1 antibodies are immunological tools designed to detect and quantify this protein in research or diagnostic contexts. These antibodies are pivotal in studying TNNC1 expression, localization, and function in physiological and pathological conditions, such as hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and muscular dystrophies.
Developed using recombinant TNNC1 protein or peptide fragments, TNNC1 antibodies are validated for specificity in techniques like Western blotting, immunohistochemistry, and ELISA. They help identify TNNC1 mutations linked to inherited cardiomyopathies or assess its dysregulation in heart failure. Some clinical applications include differentiating cardiac injury causes or evaluating troponin isoform switching in disease progression. Challenges include cross-reactivity with fast skeletal troponin C (TNNC2) due to structural homology, necessitating careful validation. Recent studies also explore TNNC1's role in non-muscle tissues, broadening its potential research scope. Overall, TNNC1 antibodies remain essential for advancing cardiovascular and neuromuscular disease mechanisms and therapeutic strategies.
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