| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FKBP36 |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FKBP6抗体的3篇文献示例(内容为虚构，仅作格式参考)：
1. **文献名称**：*FKBP6 regulates homologous recombination in meiosis via its antibody-specific interactions*
**作者**：Smith A, et al.
**摘要**：研究利用FKBP6抗体揭示了该蛋白在减数分裂中通过调控同源重组维持基因组稳定的机制，抗体特异性验证显示其在生殖细胞中的高表达。
2. **文献名称**：*FKBP6 antibody-based detection in ovarian cancer progression*
**作者**：Chen L, et al.
**摘要**：通过免疫组化(IHC)和Western blot分析，发现FKBP6在卵巢癌组织中异常表达，其抗体可用于临床样本中肿瘤分期的生物标志物研究。
3. **文献名称**：*Structural insights into FKBP6-antibody complexes for targeted therapy*
**作者**：Wang X, et al.
**摘要**：利用FKBP6抗体解析了其蛋白结构域特征，并提出该抗体在开发针对癌症和免疫疾病的靶向治疗中的潜在应用。
(注：以上文献信息为模拟生成，实际引用请通过学术数据库检索。)
The FKBP6 antibody targets the FK506-binding protein 6 (FKBP6), a member of the FKBP family characterized by peptidyl-prolyl isomerase (PPIase) activity. FKBP6 is involved in protein folding, chromatin remodeling, and regulation of cellular signaling pathways. It plays a critical role in male fertility by participating in homologous chromosome pairing during meiosis. Additionally, FKBP6 is implicated in genomic imprinting disorders, as its gene resides within the Prader-Willi/Angelman syndrome-critical region on chromosome 15. Deletions or mutations in FKBP6 are associated with Prader-Willi syndrome and oligozoospermia.
The FKBP6 antibody is widely used in research to study its expression, localization, and interactions in tissues, particularly in the testis, brain, and cancer cells. It aids in elucidating FKBP6's role in spermatogenesis, neurological development, and tumor progression. Commercial FKBP6 antibodies are typically raised against recombinant protein fragments or synthetic peptides, validated via Western blot, immunohistochemistry, and immunofluorescence. Cross-reactivity with other FKBP family members is a key consideration during experimental design. Recent studies also explore FKBP6's potential as a biomarker in cancers, such as ovarian and lung adenocarcinoma, where dysregulated expression correlates with prognosis. This antibody remains a vital tool for dissecting FKBP6's multifunctional biology and its implications in human diseases.
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