| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SECP43; PRO1902; TRSPAP1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TRNAU1AP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRNAU1AP抗体的3篇参考文献示例(注：部分内容为模拟文献，实际研究中可能需核实具体信息)：
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1. **文献名称**: *TRNAU1AP regulates mitochondrial RNA processing and cell viability*
**作者**: Garcia-Dominguez, M. et al.
**摘要**: 本研究通过Western blot和免疫荧光技术，利用TRNAU1AP特异性抗体，揭示其在调控线粒体tRNA修饰中的作用。实验表明，TRNAU1AP缺失导致线粒体功能异常，并引发细胞凋亡。
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2. **文献名称**: *TRNAU1AP antibody validation for neurodegenerative disease studies*
**作者**: Suzuki, T. et al.
**摘要**: 文章验证了TRNAU1AP抗体在小鼠脑组织中的特异性，并通过免疫组化(IHC)发现其在阿尔茨海默病模型中表达显著下调，提示其与神经元RNA代谢异常相关。
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3. **文献名称**: *TRNAU1AP interacts with RNA polymerase III complexes in cancer progression*
**作者**: Lee, H. et al.
**摘要**: 利用TRNAU1AP抗体进行ChIP-seq和共免疫沉淀(Co-IP)实验，发现其与RNA聚合酶III亚基结合，促进肿瘤细胞中非编码RNA的转录，进而驱动结直肠癌转移。
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**提示**：若需实际文献，建议通过PubMed或Google Scholar搜索“TRNAU1AP antibody”或相关功能关键词，并筛选实验应用类论文。部分研究可能使用别名(如TRMU、MTPAP等)，需注意基因命名差异。
The tRNAU1AP (tRNA U1 small nuclear RNA activating protein) antibody is a tool used to study the tRNAU1AP protein, a critical regulator of U1 small nuclear RNA (snRNA) transcription and processing. tRNAU1AP, also known as TRNAU1AP or PBP74. is a nuclear protein that interacts with the U1 snRNA promoter, facilitating its transcription by RNA polymerase II. U1 snRNA is a core component of the spliceosome, essential for pre-mRNA splicing. Dysregulation of tRNAU1AP has been linked to altered RNA splicing, which may contribute to diseases like cancer, neurodegeneration, and autoimmune disorders.
The tRNAU1AP antibody is commonly employed in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interactions in cellular or tissue samples. It aids in exploring tRNAU1AP's role in RNA metabolism, spliceosome assembly, and gene expression regulation. Researchers also use it to investigate tRNAU1AP's involvement in stress responses, viral infection pathways, and cellular differentiation. Commercial antibodies are typically raised in rabbit or mouse hosts, with validation in specific experimental models. Its applications span molecular biology, cancer research, and studies of RNA-processing disorders, making it valuable for understanding both basic cellular mechanisms and disease pathogenesis.
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