Rabbit Polyclonal WARS2 Antibody

WARS2 antibody targets the tryptophanyl-tRNA synthetase 2. mitochondrial (WARS2), a nuclear-encoded enzyme critical for mitochondrial protein synthesis. As a member of the aminoacyl-tRNA synthetase (ARS) family, WARS2 catalyzes the attachment of tryptophan to its cognate tRNA, ensuring accurate translation of mitochondrial DNA-encoded proteins essential for oxidative phosphorylation. Mutations in the WARS2 gene are linked to mitochondrial disorders, including early-onset Parkinson’s disease, Leigh syndrome, and other neurodegenerative or metabolic conditions characterized by impaired energy production. Research on WARS2 antibodies focuses on understanding its role in mitochondrial dysfunction, disease mechanisms, and potential therapeutic targets. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect WARS2 expression levels, subcellular localization, and interactions in cellular or tissue models. Recent studies also explore its involvement in cellular stress responses and apoptosis regulation. By enabling precise detection of WARS2. these antibodies contribute to advancing diagnostics and mechanistic insights into mitochondrial pathologies, highlighting their importance in both basic research and clinical applications.