| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | WAVE; SCAR1; WAVE1; NEDALVS |
| WB Predicted band size | 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human WASF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于WASF1抗体的参考文献及其摘要概括(文献信息为模拟示例，实际需根据真实文献调整)：
---
1. **文献名称**: *WASF1 promotes breast cancer invasion and metastasis through Wnt/β-catenin signaling*
**作者**: Sossey-Alaoui K, et al.
**摘要**: 本研究利用WASF1抗体通过Western blot和免疫荧光技术，证实WASF1在侵袭性乳腺癌细胞中高表达，并通过激活Wnt/β-catenin通路增强肿瘤细胞的迁移和侵袭能力。
2. **文献名称**: *Targeting WASF1 suppresses colorectal cancer metastasis by inhibiting actin cytoskeleton remodeling*
**作者**: Teng Y, et al.
**摘要**: 通过shRNA敲低WASF1并结合其抗体的免疫组化分析，发现WASF1在结肠癌转移中通过调控肌动蛋白骨架重组促进侵袭，提示其作为治疗靶点的潜力。
3. **文献名称**: *WASF1-mediated cytoskeletal dynamics regulate endothelial cell permeability and tumor angiogenesis*
**作者**: Kurisu S, Takenawa T.
**摘要**: 使用WASF1抗体进行共免疫沉淀实验，揭示WASF1通过与ARP2/3复合物相互作用调控内皮细胞通透性，影响肿瘤血管生成及转移过程。
---
**备注**：以上文献信息为示例，实际引用需核实真实文献(可通过PubMed/Google Scholar检索关键词“WASF1 antibody”或“WASF1 function”获取)。
The WASF1 antibody is a crucial tool for studying the WASF1 protein, also known as Wiskott-Aldrich syndrome protein family member 1 or SCAR/WAVE1. WASF1 belongs to the WAVE/SCAR family of proteins, which regulate actin cytoskeleton dynamics by activating the ARP2/3 complex, a key driver of branched actin network formation. This protein plays a vital role in cell motility, adhesion, and membrane protrusion processes, particularly in migrating cells. Dysregulation of WASF1 has been implicated in cancer metastasis, neuronal development, and immune cell function, making it a focal point in cancer biology and developmental research.
The WASF1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect WASF1 expression and localization in cells or tissues. Researchers employ it to investigate mechanisms underlying tumor invasion, epithelial-mesenchymal transition (EMT), and metastatic pathways. Additionally, it aids in exploring WASF1's interactions with signaling molecules such as Rac GTPase and its regulatory complexes. Commercial WASF1 antibodies are typically validated for specificity and sensitivity, often targeting conserved regions like the N-terminus. Understanding WASF1's role through antibody-based assays contributes to potential therapeutic strategies targeting cytoskeletal remodeling in diseases like cancer.
×
