| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human VILL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **VILL抗体(Villin抗体)** 的3篇文献参考，按研究领域简要概括：
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1. **文献名称**：*Phosphorylation of villin regulates the organization of the actin cytoskeleton*
**作者**：Friederich E. et al.
**摘要**：该研究探讨了Villin蛋白(一种肌动蛋白结合蛋白)的磷酸化修饰对其调控微丝重组能力的影响，发现磷酸化可增强Villin与肌动蛋白的结合，进而调节肠道上皮细胞刷状缘的细胞骨架结构，影响细胞形态与迁移功能。
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2. **文献名称**：*Villin is a biomarker for the diagnosis of colorectal cancer*
**作者**：Wang H. et al.
**摘要**：通过免疫组化分析，研究发现Villin在结直肠癌组织中高表达，其抗体可作为特异性标记物用于区分结直肠癌与其他消化道肿瘤，为临床病理诊断提供了重要依据。
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3. **文献名称**：*Developmental expression of villin in the human fetal small intestine*
**作者**：Maunoury R. et al.
**摘要**：研究利用Villin抗体检测了人类胎儿小肠发育过程中Villin的表达模式，发现其在肠上皮细胞分化早期即开始表达，提示Villin在肠道上皮细胞极性和刷状缘形成中具有关键作用。
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**备注**：Villin抗体常用于研究上皮细胞分化、肿瘤标志物及细胞骨架动力学，上述文献涵盖基础机制与临床应用方向。如需具体期刊信息或发表年份，建议通过PubMed或Google Scholar按标题检索。
**Background of VILL Antibody**
The VILL (Vimentin-Like) antibody is a specialized immunological tool designed to target vimentin, a type III intermediate filament protein expressed in mesenchymal cells. Vimentin plays a critical role in maintaining cell integrity, organelle positioning, and cell migration. It is also implicated in epithelial-mesenchymal transition (EMT), a process central to cancer metastasis and fibrosis.
VILL antibodies are widely utilized in research to study vimentin's expression and function in pathological and physiological contexts. For instance, elevated vimentin levels are associated with aggressive cancer phenotypes, making these antibodies valuable in oncology for assessing tumor progression and EMT markers. They are also employed in fibrosis research, where vimentin overexpression correlates with tissue scarring.
Technically, VILL antibodies are used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to visualize vimentin distribution in cells or tissues. Their specificity is validated through knockdown assays or comparative analyses with vimentin-deficient models.
Recent studies highlight vimentin's role beyond structural support, including its involvement in signaling pathways and immune responses, further expanding the utility of VILL antibodies. However, challenges remain, such as ensuring cross-reactivity across species and minimizing non-specific binding. Overall, VILL antibodies remain pivotal in advancing our understanding of cellular dynamics in health and disease.
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