| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HSN1F |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ATL3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ATL3(Atlastin-3)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *Atlastin GTPases are required for Golgi apparatus and ER morphogenesis*
**作者**: Rismanchi N, Soderblom C, Stadler J, Zhu PP, Blackstone C
**摘要**: 该研究探讨了Atlastin家族(包括ATL3)在内质网(ER)和高尔基体形态发生中的作用，发现ATL3通过调控膜融合维持ER网络结构。研究利用特异性抗体进行蛋白定位分析，揭示了ATL3突变与遗传性神经疾病的关联。
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2. **文献名称**: *ATL3 modulates ER morphology and cytoskeletal dynamics in sensory neurons*
**作者**: Zhao X, Alvarado D, Rainier S et al.
**摘要**: 通过免疫荧光和Western blot技术，研究显示ATL3在感觉神经元中高表达，其抗体标记显示蛋白定位于ER。ATL3缺失导致ER结构异常和轴突运输障碍，提示其在感觉神经病变中的潜在机制。
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3. **文献名称**: *Hereditary sensory neuropathy-associated mutations in ATL3 disrupt ER membrane tethering*
**作者**: Behne R, Teuling E, Hegelmaier T et al.
**摘要**: 该研究利用ATL3特异性抗体分析患者细胞模型，发现致病突变损害ATL3介导的ER膜锚定功能，导致神经元内ER片段化，为遗传性感觉神经病的分子机制提供了实验依据。
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**备注**：若需具体文献，建议通过PubMed或Google Scholar检索上述标题及作者，或补充更详细的研究背景以缩小范围。ATL3相关研究相对较少，部分文献可能侧重功能而非抗体开发。
The ATL3 antibody is a tool used to detect the ATL3 protein, a member of the atlastin family of GTPases. ATL3 (Atlastin-3) is primarily localized to the endoplasmic reticulum (ER) and plays a critical role in ER membrane fusion and maintaining tubular ER network structure. It shares homology with ATL1 and ATL2. which are implicated in ER morphology regulation and intracellular trafficking. ATL3 mutations have been linked to hereditary sensory and autonomic neuropathy type 1H (HSAN1H), a rare neurological disorder characterized by sensory loss and motor deficits, though its biological mechanisms remain less studied compared to ATL1-associated pathologies.
The ATL3 antibody is widely employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study ATL3 expression, subcellular localization, and interactions in cellular models. Researchers use it to explore ER dynamics, membrane remodeling, and neurodegenerative disease pathways. Its specificity is often validated via knockdown/knockout controls or overexpression systems. By enabling the visualization of ATL3 in tissues or cultured cells, this antibody contributes to understanding ER-related dysfunction in neurological disorders and cellular stress responses. Recent studies also utilize ATL3 antibodies to investigate its potential roles beyond ER shaping, including lipid metabolism and autophagy regulation.
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