| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ASXH2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ASXL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ASXL2抗体的模拟参考文献示例(注：实际文献需通过学术数据库查询)：
1. **文献名称**：*ASXL2 mutations promote myeloid transformation through loss of PRC2-mediated gene repression*
**作者**：Wang C. et al.
**摘要**：研究利用ASXL2抗体进行免疫沉淀和ChIP-seq分析，发现ASXL2突变通过破坏PRC2复合体的表观遗传调控功能，促进骨髓增生异常综合征向白血病转化。
2. **文献名称**：*ASXL2 interacts with cohesin to maintain chromatin integrity in hematopoietic stem cells*
**作者**：Li Z. et al.
**摘要**：通过ASXL2抗体的Western blot和免疫荧光实验，揭示ASXL2与黏连蛋白复合体协同维持造血干细胞染色质稳定性，缺失导致基因组不稳定性。
3. **文献名称**：*Development and validation of a specific ASXL2 antibody for immunohistochemical analysis in solid tumors*
**作者**：Zhang Y. et al.
**摘要**：报道一种高特异性ASXL2抗体的开发，并验证其在乳腺癌和肺癌组织中的免疫组化应用，发现ASXL2表达与患者预后相关。
4. **文献名称**：*ASXL2 regulates lipid metabolism via PPARγ signaling in adipocytes*
**作者**：Kim H. et al.
**摘要**：利用ASXL2抗体敲低实验，证明ASXL2通过调控PPARγ通路影响脂肪细胞分化及脂质代谢，为代谢性疾病提供新机制。
**建议**：通过PubMed或Google Scholar搜索“ASXL2 antibody”或“ASXL2 function”获取最新文献，关注其表观遗传调控及疾病机制研究。
The ASXL2 antibody is a research tool used to detect and study the Additional Sex Combs-Like 2 (ASXL2) protein, a member of the ASXL family of chromatin-binding proteins. ASXL proteins (ASXL1-3) play roles in epigenetic regulation by modulating chromatin structure and gene expression through interactions with polycomb repressive complexes (PRC) and other transcriptional regulators. ASXL2. specifically, is involved in deubiquitination processes via its partnership with BAP1 (BRCA1-associated protein 1), influencing histone H2A ubiquitination and transcriptional activation or repression.
ASXL2 is implicated in normal hematopoiesis, embryonic development, and stem cell maintenance. Dysregulation or mutations in ASXL2 have been linked to cancers, including acute myeloid leukemia (AML), though its role is less characterized compared to ASXL1. ASXL2 antibodies are critical for investigating its expression patterns, subcellular localization, and functional interactions in both physiological and pathological contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein levels in cell lines or tissues. Researchers also utilize ASXL2 antibodies to explore its involvement in disease mechanisms, such as aberrant chromatin remodeling in malignancies. However, challenges remain in ensuring antibody specificity due to structural similarities among ASXL family members. Validation using knockout controls or siRNA knockdown is essential for reliable results. Ongoing studies aim to clarify ASXL2's dual roles as a tumor suppressor or oncogene, depending on cellular context.
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