| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CRL1; CRLZ1; SAS10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human UTP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UTP3抗体的3篇示例参考文献(注：文献为虚构示例，仅供参考格式和内容框架)：
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1. **文献名称**: *UTP3 is essential for pre-rRNA processing and ribosome biogenesis in human cells*
**作者**: Smith, J., Lee, A., & Garcia, R.
**摘要**: 本研究利用UTP3特异性抗体，通过免疫荧光和Western blot技术，揭示了UTP3蛋白在核仁中的定位及其在18S rRNA前体加工中的关键作用。敲低UTP3导致rRNA成熟受阻和细胞周期停滞，表明其在核糖体组装中的必要性。
2. **文献名称**: *A novel UTP3 antibody reveals dysregulation in triple-negative breast cancer models*
**作者**: Chen, X., Wang, Y., & Patel, S.
**摘要**: 作者开发了一种高特异性抗UTP3单克隆抗体，并用于分析乳腺癌细胞系。研究发现，UTP3在三阴性乳腺癌中表达显著上调，且其缺失抑制肿瘤细胞增殖，提示其作为潜在治疗靶点的价值。
3. **文献名称**: *UTP3 interacts with the snoRNP complex: Insights from CRISPR/Cas9-mediated knockout studies*
**作者**: Müller, T., Schneider, D., & Braun, M.
**摘要**: 通过CRISPR/Cas9敲除UTP3基因并结合抗体共免疫沉淀(Co-IP)，发现UTP3与snoRNP复合物相互作用，调控rRNA甲基化修饰。研究为UTP3在表观遗传调控中的功能提供了新证据。
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**说明**：
- 实际研究中，建议通过PubMed或Google Scholar搜索真实文献(关键词：UTP3 antibody, C1D/UTP3. ribosome biogenesis)。
- UTP3相关研究可能涉及核糖体合成、癌症或遗传疾病，抗体多用于定位、蛋白互作或表达分析。
The UTP3 antibody is a tool used to study the UTP3 protein, a component of the small subunit (SSU) processome, a large ribonucleoprotein complex critical for ribosomal RNA (rRNA) biogenesis. UTP3. also known as NOL14 or C1orf107. plays a role in the early stages of 18S rRNA processing within the nucleolus, facilitating the cleavage and modification of precursor rRNA (pre-rRNA) to form mature ribosomal subunits. As part of the UTP (U Three Protein) complex, it contributes to ribosome assembly, linking ribosome synthesis to cellular growth and proliferation.
Antibodies targeting UTP3 are utilized in research to investigate its expression, localization, and interactions, employing techniques like Western blotting, immunofluorescence, and immunoprecipitation. These studies are essential for understanding ribosomopathies—diseases caused by defective ribosome biogenesis—and cancers where dysregulated rRNA synthesis is common. For example, UTP3 overexpression has been implicated in tumorigenesis, making it a potential biomarker or therapeutic target.
The UTP3 antibody also aids in exploring developmental disorders linked to ribosomal dysfunction, such as Diamond-Blackfan anemia. By elucidating UTP3's role in rRNA maturation and its interplay with other SSU processome components, researchers gain insights into fundamental cellular processes and disease mechanisms. Commercial UTP3 antibodies are typically validated for specificity across human, mouse, or rat models, supporting diverse experimental applications.
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