| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CRYG8; CTRCT20 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CRYGS抗体的模拟参考文献示例(注：以下内容为基于领域知识的合理推测，非真实存在的文献，建议通过学术数据库检索获取最新研究)：
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1. **文献名称**：*CRYGS expression and localization during murine lens development*
**作者**：Smith A, et al.
**摘要概述**：本研究利用CRYGS特异性抗体，通过免疫组化和Western blot分析了小鼠晶状体发育过程中CRYGS蛋白的动态表达模式，发现其在胚胎后期至出生早期的纤维细胞分化中起关键作用，为先天性白内障机制提供了线索。
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2. **文献名称**：*A novel CRYGS mutation linked to autosomal dominant congenital cataract*
**作者**：Zhang L, et al.
**摘要概述**：研究者通过基因测序在一家族性先天性白内障病例中发现了CRYGS基因的错义突变，并利用CRYGS抗体证实突变蛋白在晶状体上皮细胞中异常聚集，导致光散射增强，揭示了其病理机制。
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3. **文献名称**：*Structural insights into γS-crystallin stability via cryo-EM and antibody mapping*
**作者**：Brown K, et al.
**摘要概述**：结合冷冻电镜和CRYGS抗体的表位定位，本研究解析了γS-晶状体蛋白在氧化应激下的构象变化，阐明其N端结构域对维持蛋白稳定性的重要性，为开发白内障干预策略提供依据。
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4. **文献名称**：*CRYGS knockout mice exhibit age-related lens opacification*
**作者**：Chen R, et al.
**摘要概述**：通过构建CRYGS基因敲除小鼠模型，并利用CRYGS抗体验证蛋白缺失，研究发现CRYGS缺失导致成年小鼠晶状体纤维细胞结构紊乱，提示其在维持晶状体透明度中的持续作用。
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建议通过PubMed或Google Scholar检索关键词“CRYGS antibody”、“gammaS-crystallin”或“congenital cataract CRYGS”获取真实文献。
CRYGS (Crystallin Gamma S) is a member of the crystallin protein family, primarily expressed in the vertebrate eye lens. Crystallins, including α-, β-, and γ-subfamilies, are critical for maintaining lens transparency and refractive index. Among γ-crystallins, CRYGS is a key structural component that contributes to lens elasticity and optical clarity by preventing protein aggregation. Mutations in the CRYGS gene are associated with congenital cataracts, highlighting its role in lens homeostasis.
CRYGS antibodies are immunological tools designed to detect and study the expression, localization, and function of the CRYGS protein. These antibodies are widely used in research to investigate lens development, aging, and cataractogenesis. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize CRYGS distribution in lens tissues or cell models. Studies utilizing CRYGS antibodies have explored its interaction with other crystallins, stress-response pathways, and mechanisms underlying lens opacification. Additionally, they aid in characterizing animal models of cataracts or transgenic systems with CRYGS alterations. Commercially available CRYGS antibodies are typically validated for specificity via knockout controls or peptide blocking assays. Ongoing research focuses on CRYGS's potential role beyond the lens, including possible involvement in non-ocular tissues, though its primary significance remains in ocular biology and disease.
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