| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CGI-143 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及BOLA1抗体的研究文献摘要(文献标题和作者为虚构模拟，供参考)：
1. **文献名称**：BOLA1在氧化应激中的线粒体定位及功能研究
**作者**：Smith A, et al. (2016)
**摘要**：通过免疫荧光和Western blot技术验证BOLA1抗体特异性，发现BOLA1定位于线粒体，并在活性氧(ROS)应激条件下表达上调，提示其参与线粒体氧化防御机制。
2. **文献名称**：BOLA1与铁硫簇组装蛋白互作的功能分析
**作者**：Zhang L, et al. (2018)
**摘要**：利用BOLA1抗体进行免疫共沉淀实验，证实BOLA1与GLRX5蛋白存在相互作用，可能通过调控铁硫簇生物合成影响细胞代谢稳态。
3. **文献名称**：BOLA1在癌症中的异常表达及其临床意义
**作者**：Chen R, et al. (2020)
**摘要**：基于BOLA1抗体的组织芯片分析显示，BOLA1在肝癌组织中显著低表达，且与患者预后不良相关，提示其可能作为潜在肿瘤抑制因子。
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**说明**：以上内容为模拟示例，实际文献需通过PubMed或Google Scholar搜索关键词“BOLA1 antibody”或“BOLA1 function”获取。建议参考近五年内发表的实验类论文(如涉及Western blot、免疫组化等抗体应用的研究)。
The BOLA1 antibody targets the BolA family member 1 protein, a highly conserved protein implicated in cellular iron-sulfur (Fe-S) cluster metabolism and redox homeostasis. BOLA1 is localized to mitochondria and interacts with glutaredoxin-5 (GLRX5), playing a role in Fe-S cluster biogenesis—a critical process for enzymes involved in DNA repair, energy production, and antioxidant defense. Studies suggest BOLA1 may act as a redox-sensitive regulator, balancing Fe-S cluster distribution under oxidative stress conditions.
BOLA1 antibodies are primarily used in research to investigate mitochondrial dysfunction, oxidative stress-related diseases, and Fe-S cluster-associated disorders. They enable detection of BOLA1 expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Emerging evidence links BOLA1 dysregulation to neurodegenerative diseases, cancer, and rare genetic disorders, driving interest in its mechanistic roles.
Despite its conserved structure across eukaryotes, BOLA1's precise molecular functions remain under exploration. Antibodies against BOLA1 help clarify its tissue-specific expression patterns, subcellular localization, and interaction networks. Recent studies also explore its potential as a biomarker for mitochondrial pathologies. However, commercial availability of BOLA1 antibodies is limited, emphasizing the need for rigorous validation to ensure specificity in experimental models. Ongoing research aims to unravel its therapeutic relevance in diseases tied to Fe-S cluster imbalance.
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