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Rabbit Polyclonal BHMT2 Antibody

  • 中文名: BHMT2抗体
  • 别    名: nan
货号: IPDX09361
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

WB Predicted band size40 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human BHMT2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于BHMT2抗体的模拟参考文献示例(仅供参考,具体文献需通过学术数据库核实):

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1. **文献名称**:*Characterization of BHMT2 in one-carbon metabolism and its role in mitochondrial function*

**作者**:Smith J, et al.

**摘要**:该研究利用BHMT2特异性抗体,通过免疫印迹和免疫荧光技术,揭示了BHMT2在线粒体中的定位及其在调控一碳代谢中的关键作用,发现其缺失会导致同型半胱氨酸代谢异常。

2. **文献名称**:*Development and validation of a polyclonal antibody against human BHMT2 for clinical diagnostics*

**作者**:Li X, Wang Y, et al.

**摘要**:本文报道了一种新型BHMT2多克隆抗体的制备与验证,通过ELISA和免疫组化证实其高特异性和敏感性,适用于肝组织样本中BHMT2蛋白表达的定量检测。

3. **文献名称**:*BHMT2 expression correlates with oxidative stress in neurodegenerative diseases*

**作者**:Chen R, et al.

**摘要**:研究通过BHMT2抗体分析阿尔茨海默病模型小鼠脑组织,发现BHMT2表达下调与氧化应激水平升高相关,提示其可能通过调节硫代谢参与神经退行性病变。

4. **文献名称**:*BHMT2 as a potential biomarker in hepatocellular carcinoma: Insights from antibody-based proteomic profiling*

**作者**:Garcia M, et al.

**摘要**:利用BHMT2抗体进行蛋白质组学分析,发现肝癌组织中BHMT2表达显著上调,提示其可能作为肝癌早期诊断或治疗靶点的潜在生物标志物。

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**注意**:以上文献为示例,实际引用需查阅PubMed、Web of Science等数据库获取真实文献。建议结合具体研究领域补充关键词(如“BHMT2 antibody validation”或“BHMT2 immunohistochemistry”)进行精准检索。

背景信息

The BHMT2 antibody is a research tool used to detect and study Betaine-Homocysteine S-Methyltransferase 2 (BHMT2), an enzyme involved in the methionine cycle and homocysteine metabolism. BHMT2 catalyzes the conversion of homocysteine to methionine using S-methylmethionine as a methyl donor, complementing the function of BHMT1. which uses betaine. This enzyme plays a role in maintaining cellular methylation potential and redox balance, particularly in tissues like the liver and kidneys. BHMT2 is structurally related to BHMT1 but exhibits distinct substrate preferences and regulatory mechanisms. Its expression and activity are linked to folate-independent pathways, making it relevant in conditions influenced by homocysteine levels, such as cardiovascular diseases, liver disorders, and neurological impairments. The BHMT2 antibody enables researchers to investigate protein expression patterns, subcellular localization, and tissue distribution via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using this antibody have explored BHMT2's role in metabolic syndromes, genetic polymorphisms affecting enzyme efficiency, and its interplay with dietary factors. However, commercial availability and validation data may vary, requiring careful optimization in experimental settings. Understanding BHMT2's function through antibody-based assays contributes to insights into sulfur amino acid metabolism and therapeutic targeting of related pathologies.

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