首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal NCAPH Antibody

  • 中文名: NCAPH抗体
  • 别    名: CAPH; BRRN1; CAP-H; MCPH23
货号: IPDX09375
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesCAPH; BRRN1; CAP-H; MCPH23
WB Predicted band size83 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human NCAPH
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于NCAPH抗体的3篇参考文献的简要信息,供参考:

1. **文献名称**:NCAPH regulates the proliferation and metastasis of lung cancer cells

**作者**:Li X, et al.

**摘要**:该研究利用NCAPH抗体进行免疫印迹和免疫组化实验,发现NCAPH在肺癌组织中高表达,并促进癌细胞增殖和转移,提示其作为潜在治疗靶点。

2. **文献名称**:Condensin subunit NCAPH2 interacts with ERα to promote breast cancer progression

**作者**:Wang Y, et al.

**摘要**:通过免疫共沉淀(Co-IP)结合NCAPH抗体的实验,揭示了NCAPH与雌激素受体α(ERα)互作,增强乳腺癌细胞侵袭能力及化疗耐药性。

3. **文献名称**:Dynamic localization of NCAPH during mitosis and its role in chromosome condensation

**作者**:Hirota T, et al.

**摘要**:利用NCAPH抗体的免疫荧光技术,追踪NCAPH在有丝分裂期的动态定位,证实其通过调控染色体凝缩过程维持基因组稳定性。

注:以上文献信息为示例,实际文献需通过PubMed或Sci-Hub等平台检索具体标题验证。研究关键词建议:NCAPH antibody、condensin complex、cancer biology。

背景信息

The NCAPH antibody targets the Non-SMC Condensin I Complex Subunit H (NCAPH), a key component of the condensin I complex essential for chromosome condensation and segregation during mitosis. Condensin I, composed of SMC2. SMC4. and three non-SMC subunits (NCAPD2. NCAPH, and NCAPG), ensures proper chromatin organization by compacting chromosomes and resolving sister chromatids. NCAPH stabilizes the complex, enabling ATPase-driven structural changes critical for DNA loop formation and mitotic fidelity. Dysregulation of NCAPH is linked to genomic instability, aneuploidy, and cancer progression. NCAPH antibodies are widely used in research to study chromosome dynamics, cell cycle regulation, and mitotic errors. They enable detection via Western blotting, immunofluorescence, and immunohistochemistry, helping elucidate NCAPH's role in developmental disorders and malignancies. Recent studies highlight its overexpression in tumors, correlating with poor prognosis, making it a potential therapeutic target. These antibodies also aid in exploring condensin I's interaction with other chromatin modifiers and its involvement in DNA repair. Available as monoclonal or polyclonal variants, NCAPH antibodies are vital tools for understanding genome organization and mitotic mechanisms.

客户数据及评论

折叠内容

大包装询价

×