| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HEL-206; HEL-S-94 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human C12orf40 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的关于C12orf40抗体的参考文献示例(请注意，以下内容为假设性文献，建议通过学术数据库验证真实研究)：
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1. **文献名称**：*C12orf40 Expression and Its Role in DNA Damage Repair*
**作者**：Zhang L, et al.
**摘要**：本研究利用兔源多克隆C12orf40抗体，通过Western blot和免疫荧光技术证实C12orf40蛋白在HeLa细胞中的核定位，并发现其参与调控DNA损伤修复通路，可能与癌症治疗耐药性相关。
2. **文献名称**：*Characterization of C12orf40 as a Novel Tumor Suppressor in Colorectal Cancer*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化分析临床样本，发现C12orf40在结直肠癌组织中表达下调。使用小鼠单克隆C12orf40抗体验证其表达缺失与患者预后不良显著相关，提示其抑癌功能。
3. **文献名称**：*C12orf40 Antibody Validation for Flow Cytometry Applications*
**作者**：Johnson R, et al.
**摘要**：本文系统验证了商业化的C12orf40抗体(货号AB123)在流式细胞术中的特异性，确认其在淋巴细胞亚群中的差异表达，为免疫学研究提供可靠工具。
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建议通过 **PubMed** 或 **Google Scholar** 以“C12orf40 antibody”、“C12orf40 protein function”为关键词检索最新文献，或查阅抗体供应商(如Abcam、Sigma-Aldrich)的产品引用列表获取实际研究。
The C12orf40 antibody is a research tool designed to target the protein encoded by the *C12orf40* gene (Chromosome 12 Open Reading Frame 40), a relatively understudied gene located on human chromosome 12. Although its exact biological function remains unclear, *C12orf40* is hypothesized to play roles in cellular processes such as DNA repair, transcriptional regulation, or cell cycle control, based on structural motifs and limited interactome studies. The gene is expressed across various tissues, with higher mRNA levels observed in the testes, suggesting potential involvement in reproductive biology.
C12orf40 has garnered interest due to emerging associations with diseases. For example, altered expression of *C12orf40* has been reported in certain cancers, including prostate and gastric cancers, implying a possible link to tumorigenesis or metastasis. The C12orf40 antibody, typically developed in rabbit or mouse hosts, enables researchers to investigate the protein's expression patterns, subcellular localization (predominantly nuclear), and interactions via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). These studies aim to clarify its physiological roles and pathological relevance.
Despite limited commercial availability, custom C12orf40 antibodies are increasingly utilized in exploratory studies, particularly in oncology and molecular biology. Validating these antibodies remains critical, given the gene's low annotation status and potential cross-reactivity concerns. Ongoing research seeks to unravel its molecular mechanisms, potentially positioning C12orf40 as a biomarker or therapeutic target in disease contexts.
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