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Rabbit Polyclonal UBR7 Antibody

  • 中文名: UBR7抗体
  • 别    名: C14orf130
货号: IPDX09385
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

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参考文献

以下是关于UBR7抗体的参考文献示例(注:以下内容为模拟生成,实际文献需通过学术数据库验证):

1. **"UBR7 regulates histone H2B monoubiquitination and cellular proliferation"**

*Authors: Tasaki T, et al.*

**摘要**: 本研究利用UBR7特异性抗体,通过免疫沉淀和染色质免疫共沉淀(ChIP)技术,揭示了UBR7作为E3泛素连接酶催化组蛋白H2B单泛素化的功能,并证明其缺失导致细胞周期调控异常。

2. **"The role of UBR7 in DNA damage response via p53 stabilization"**

*Authors: Suzuki M, et al.*

**摘要**: 通过Western blot和免疫荧光实验(使用UBR7抗体),作者发现UBR7通过抑制MDM2介导的p53降解,增强DNA损伤后p53的稳定性,从而调控细胞凋亡通路。

3. **"UBR7 expression correlates with prognosis in breast cancer"**

*Authors: Kim Y, et al.*

**摘要**: 研究利用UBR7抗体进行免疫组化分析,发现UBR7在乳腺癌组织中表达显著下调,其低表达与患者预后不良相关,提示其可能作为肿瘤抑制因子发挥作用。

4. **"Structural and functional characterization of UBR7 ubiquitin ligase"**

*Authors: Nguyen AT, et al.*

**摘要**: 该文献通过UBR7抗体的表位定位和体外泛素化实验,解析了UBR7的底物结合结构域及其在泛素-蛋白酶体系统中的分子机制。

**建议**:可通过PubMed或Google Scholar以关键词“UBR7 antibody”、“UBR7 ubiquitin ligase”检索最新文献,部分研究可能涉及抗体在特定疾病模型或机制探索中的应用。

背景信息

The UBR7 antibody is a research tool used to study the ubiquitin-protein ligase E3 component n-recognin 7 (UBR7), a member of the UBR box-containing protein family. UBR7 is implicated in the N-end rule pathway, a ubiquitin-dependent proteolytic system that targets specific proteins for degradation based on their N-terminal residues. Unlike other UBR family members (e.g., UBR1-UBR6), UBR7 uniquely associates with chromatin and regulates transcriptional processes, potentially through histone modification or chromatin remodeling. It contains a plant homeodomain (PHD) finger, suggesting roles in epigenetic regulation. Studies link UBR7 to tumor suppression, DNA repair, and cell cycle control, with dysregulation observed in cancers and developmental disorders. The UBR7 antibody enables detection and localization of UBR7 in cells or tissues via techniques like Western blotting, immunofluorescence, or immunohistochemistry. Its development aids investigations into UBR7's molecular mechanisms, including its interplay with polycomb repressive complexes or p53-mediated pathways. Validating antibody specificity through knockout controls or siRNA knockdown is critical due to potential cross-reactivity with homologous proteins. Research using UBR7 antibodies contributes to understanding diseases linked to ubiquitin-proteasome dysfunction and chromatin biology.

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