| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human C17orf67 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于C17orf67抗体的模拟参考文献示例(实际研究中相关文献可能较少，建议通过PubMed或抗体供应商数据库查询最新进展)：
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1. **文献名称**: *C17orf67 Expression and Functional Analysis in Colorectal Cancer*
**作者**: Smith J, et al.
**摘要**: 本研究通过Western blot和免疫组化技术，利用C17orf67特异性抗体，揭示了该基因在结直肠癌组织中的高表达，并发现其过表达与患者预后不良相关。
2. **文献名称**: *Characterization of C17orf67 Protein Localization Using Polyclonal Antibodies*
**作者**: Lee H, et al.
**摘要**: 通过开发兔源多克隆抗体，研究者证实C17orf67蛋白主要定位于细胞核，并发现其表达水平在细胞周期S期显著上调。
3. **文献名称**: *C17orf67 as a Novel Biomarker in Neuroblastoma*
**作者**: Zhang Y, et al.
**摘要**: 使用C17orf67抗体进行免疫荧光和流式细胞术分析，发现该基因在神经母细胞瘤中的异常表达与肿瘤侵袭性相关，提示其潜在治疗靶点价值。
4. **文献名称**: *Functional Screening of C17orf67 via CRISPR and Antibody Validation*
**作者**: Garcia R, et al.
**摘要**: 研究结合CRISPR基因编辑和C17orf67抗体验证，证明该基因缺失导致细胞增殖抑制，可能通过调控Wnt信号通路发挥作用。
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**注意**：以上为模拟示例，实际文献可能需要通过学术数据库检索。若研究较少，可参考抗体供应商(如Abcam、CST)提供的技术文档或应用案例。
The C17orf67 antibody is a research tool designed to detect the protein encoded by the C17orf67 gene (Chromosome 17 Open Reading Frame 67), a locus initially identified through genomic sequencing but with limited functional characterization. This gene, also known as CCDC47 (Coiled-Coil Domain Containing 47) in some databases, is ubiquitously expressed across human tissues and is implicated in cellular processes such as protein folding, calcium homeostasis, and endoplasmic reticulum (ER) function. The encoded protein is thought to interact with ER-resident chaperones, though its precise molecular mechanisms remain under investigation.
Antibodies targeting C17orf67 are typically produced in immunized host species (e.g., rabbits or mice) using peptide antigens derived from the protein's conserved regions. These antibodies enable applications like Western blotting, immunofluorescence, and immunohistochemistry to localize and quantify the protein in biological samples. Recent studies have explored its potential roles in cancer, with altered expression observed in malignancies such as hepatocellular carcinoma and breast cancer, suggesting involvement in tumor progression or therapy resistance. However, the protein's pathophysiological relevance and biomarker potential require further validation. Commercial C17orf67 antibodies often undergo validation for specificity via knockout/knockdown controls, yet researchers are advised to confirm target specificity in their experimental systems due to occasional cross-reactivity issues. Ongoing research aims to clarify its biological functions and therapeutic implications.
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